biostudies-literaturePatti MAChemicals Management Plan at Health Canada, the Ontario Ministry of the Environment, and the Canadian Institutes for Health ResearchNIEHS NIH HHS11332https://www.ebi.ac.uk/biostudies/studies/S-EPMC9517145biostudies-literatureUnknown19(18)Gestational arsenic exposure adversely impacts child health. Folate-mediated 1-carbon metabolism facilitates urinary excretion of arsenic and may prevent arsenic-related adverse health outcomes. We investigated the potential for maternal folate status to modify associations between gestational arsenic exposure and child health. We used data from 364 mother-child pairs in the MIREC study, a prospective pan-Canadian cohort. During pregnancy, we measured first trimester urinary arsenic concentrations, plasma folate biomarkers, and folic acid supplementation intake. At age 3 years, we evaluated twelve neurodevelopmental and anthropometric features. Using latent profile analysis and multinomial regression, we developed phenotypic profiles of child health, estimated covariate-adjusted associatioInternational journal of environmental research and public healthMaternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes.PMC9517145R01 ES025214R01 ES032386R01 ES024381MOP-81285Papandonatos GDPatti MAMacFarlane AJBraun JMFisher MAshley-Martin JLanphear BPMuckle GFraser WDKelsey KTArbuckle TEfalseMaternal Folate Status and the Relation between Gestational Arsenic Exposure and Child Health Outcomes.Gestational arsenic exposure adversely impacts child health. Folate-mediated 1-carbon metabolism facilitates urinary excretion of arsenic and may prevent arsenic-related adverse health outcomes. We investigated the potential for maternal folate status to modify associations between gestational arsenic exposure and child health. We used data from 364 mother-child pairs in the MIREC study, a prospective pan-Canadian cohort. During pregnancy, we measured first trimester urinary arsenic concentrations, plasma folate biomarkers, and folic acid supplementation intake. At age 3 years, we evaluated twelve neurodevelopmental and anthropometric features. Using latent profile analysis and multinomial regression, we developed phenotypic profiles of child health, estimated covariate-adjusted associatio2022-01-01T00:00:00Z2022 Sep2025-04-19T05:16:36.034Z2025-04-19T05:16:36.034ZS-EPMC95171453614160410.3390/ijerph191811332