{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["96(18)"],"submitter":["Rodriguez-Martin D"],"pubmed_abstract":["Viruses have evolved numerous strategies to impair immunity so that they can replicate more efficiently. Among those, the immunosuppressive effects of morbillivirus infection can be particularly problematic, as they allow secondary infections to take hold in the host, worsening disease prognosis. In the present work, we hypothesized that the highly contagious morbillivirus peste des petits ruminants virus (PPRV) could target monocytes and dendritic cells (DC) to contribute to the immunosuppressive effects produced by the infection. Monocytes isolated from healthy sheep, a natural host of the disease, were able be infected by PPRV and this impaired the differentiation and phagocytic ability of immature monocyte-derived DC (MoDC). We also assessed PPRV capacity to infect differentiated MoDC."],"journal":["Journal of virology"],"pagination":["e0124022"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9517701"],"repository":["biostudies-literature"],"pubmed_title":["A Morbillivirus Infection Shifts DC Maturation Toward a Tolerogenic Phenotype to Suppress T Cell Activation."],"pmcid":["PMC9517701"],"pubmed_authors":["Martin V","Garcia-Garcia I","Rojas JM","Rodriguez-Martin D","Sevilla N"],"additional_accession":[]},"is_claimable":false,"name":"A Morbillivirus Infection Shifts DC Maturation Toward a Tolerogenic Phenotype to Suppress T Cell Activation.","description":"Viruses have evolved numerous strategies to impair immunity so that they can replicate more efficiently. Among those, the immunosuppressive effects of morbillivirus infection can be particularly problematic, as they allow secondary infections to take hold in the host, worsening disease prognosis. In the present work, we hypothesized that the highly contagious morbillivirus peste des petits ruminants virus (PPRV) could target monocytes and dendritic cells (DC) to contribute to the immunosuppressive effects produced by the infection. Monocytes isolated from healthy sheep, a natural host of the disease, were able be infected by PPRV and this impaired the differentiation and phagocytic ability of immature monocyte-derived DC (MoDC). We also assessed PPRV capacity to infect differentiated MoDC.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-06-13T06:11:20.484Z","creation":"2025-04-04T03:35:34.617Z"},"accession":"S-EPMC9517701","cross_references":{"pubmed":["36094317"],"doi":["10.1128/jvi.01240-22"]}}