{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Goonawardane N"],"funding":["Wellcome Trust"],"pagination":["e0081822"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9517736"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["96(18)"],"pubmed_abstract":["Tick-borne encephalitis virus (TBEV) is an important human arthropod-borne virus that causes tick-borne encephalitis (TBE) in humans. TBEV acutely infects the central nervous system (CNS), leading to neurological symptoms of various severity. No therapeutics are currently available for TBEV-associated disease. Virus strains of various pathogenicity have been described, although the basis of their diverse clinical outcome remains undefined. Work with infectious TBEV requires high-level biocontainment, meaning model systems that can recapitulate the virus life cycle are highly sought. Here, we report the generation of a self-replicating, noninfectious TBEV replicon used to study properties of high (Hypr) and low (Vs) pathogenic TBEV isolates. Using a Spinach2 RNA aptamer and luciferase repor"],"journal":["Journal of virology"],"pubmed_title":["Identification of Host Factors Differentially Induced by Clinically Diverse Strains of Tick-Borne Encephalitis Virus."],"pmcid":["PMC9517736"],"funding_grant_id":["096670/Z/11/Z","104918/Z/14/Z"],"pubmed_authors":["Harris M","Goonawardane N","Upstone L","Jones IM"],"additional_accession":[]},"is_claimable":false,"name":"Identification of Host Factors Differentially Induced by Clinically Diverse Strains of Tick-Borne Encephalitis Virus.","description":"Tick-borne encephalitis virus (TBEV) is an important human arthropod-borne virus that causes tick-borne encephalitis (TBE) in humans. TBEV acutely infects the central nervous system (CNS), leading to neurological symptoms of various severity. No therapeutics are currently available for TBEV-associated disease. Virus strains of various pathogenicity have been described, although the basis of their diverse clinical outcome remains undefined. Work with infectious TBEV requires high-level biocontainment, meaning model systems that can recapitulate the virus life cycle are highly sought. Here, we report the generation of a self-replicating, noninfectious TBEV replicon used to study properties of high (Hypr) and low (Vs) pathogenic TBEV isolates. Using a Spinach2 RNA aptamer and luciferase repor","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T19:40:41.312Z","creation":"2024-11-07T11:59:36.173Z"},"accession":"S-EPMC9517736","cross_references":{"pubmed":["36098513"],"doi":["10.1128/jvi.00818-22"]}}