{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["19(17)"],"submitter":["Alshammari A"],"pubmed_abstract":["The misuse of antibiotics in our daily lives has led to the emergence of antimicrobial resistance. As a result, many antibiotics are becoming ineffective. This phenomenon is linked with high rates of mortality and morbidity. Therefore, new approaches are required to address this major health issue. <i>Leptotrichia buccalis</i> is a Gram-negative, rod-shaped bacterium which normally resides in the oral and vaginal cavities. It is an emerging bacterial pathogen which is developing new antibiotic-resistance mechanisms. No approved vaccine is available against this pathogen, which is a cause for growing concern. In this study, an in silico-based, multi-epitopes vaccine against this pathogen was designed by applying reverse vaccinology and immunoinformatic approaches. Of a total of 2193 predict"],"journal":["International journal of environmental research and public health"],"pagination":["10742"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9518150"],"repository":["biostudies-literature"],"pubmed_title":["Novel Chimeric Vaccine Candidate Development against <i>Leptotrichia buccalis</i>."],"pmcid":["PMC9518150"],"pubmed_authors":["Muhseen ZT","Ullah A","Arshad M","Alharbi M","Ashfaq UA","Ud-Din M","Ahmad S","Ali N","Alasmari AF","Alshammari A"],"additional_accession":[]},"is_claimable":false,"name":"Novel Chimeric Vaccine Candidate Development against <i>Leptotrichia buccalis</i>.","description":"The misuse of antibiotics in our daily lives has led to the emergence of antimicrobial resistance. As a result, many antibiotics are becoming ineffective. This phenomenon is linked with high rates of mortality and morbidity. Therefore, new approaches are required to address this major health issue. <i>Leptotrichia buccalis</i> is a Gram-negative, rod-shaped bacterium which normally resides in the oral and vaginal cavities. It is an emerging bacterial pathogen which is developing new antibiotic-resistance mechanisms. No approved vaccine is available against this pathogen, which is a cause for growing concern. In this study, an in silico-based, multi-epitopes vaccine against this pathogen was designed by applying reverse vaccinology and immunoinformatic approaches. Of a total of 2193 predict","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-04-08T11:55:03.153Z","creation":"2025-02-19T02:24:33.708Z"},"accession":"S-EPMC9518150","cross_references":{"pubmed":["36078462"],"doi":["10.3390/ijerph191710742"]}}