biostudies-literatureBecerro-Recio DMinisterio de Ciencia, Innovación y UniversidadesConsejería de Educación, Junta de Castilla y LeónMinisterio de Ciencia e InnovaciónMinisterio de Economía, Industria y Competitividad, Gobierno de Españae0010766https://www.ebi.ac.uk/biostudies/studies/S-EPMC9518905biostudies-literatureUnknown16(9)Fasciola hepatica is a trematode parasite that infects animals and humans causing fasciolosis, a worldwide-distributed disease responsible for important economic losses and health problems. This disease is of growing public health concern since parasite isolates resistant to the current treatment (triclabendazole) have increasingly been described. F. hepatica infects its vertebrate host after ingestion of the encysted parasite (metacercariae), which are found in the water or attached to plants. Upon ingestion, newly excysted juveniles of F. hepatica (FhNEJ) emerge in the intestinal lumen and cross the intestinal barrier, reach the peritoneum and migrate to the biliary ducts, where adult worms fully develop. Despite the efforts made to develop new therapeutic and preventive tools, to date, PLoS neglected tropical diseasesStudy of the migration of Fasciola hepatica juveniles across the intestinal barrier of the host by quantitative proteomics in an ex vivo model.PMC9518905Predoctoral contractRTI2018-093463-J-100Projects AGL2015-67023-C2-2-R and AGL2015-67023-C2-1-RJuan de la Cierva IncorporaciónFPU predoctoral contractProjects PID2019-108782RB-C22 and PID2019-108782RB-C21CLU-2019-05 – IRNASA/CSIC Unit of ExcellenceSiles-Lucas MLopez-Garcia MPerez-Arevalo JBecerro-Recio DSimon FMolina-Hernandez VMartinez-Moreno ASerrat JSotillo JGonzalez-Miguel JfalseStudy of the migration of Fasciola hepatica juveniles across the intestinal barrier of the host by quantitative proteomics in an ex vivo model.Fasciola hepatica is a trematode parasite that infects animals and humans causing fasciolosis, a worldwide-distributed disease responsible for important economic losses and health problems. This disease is of growing public health concern since parasite isolates resistant to the current treatment (triclabendazole) have increasingly been described. F. hepatica infects its vertebrate host after ingestion of the encysted parasite (metacercariae), which are found in the water or attached to plants. Upon ingestion, newly excysted juveniles of F. hepatica (FhNEJ) emerge in the intestinal lumen and cross the intestinal barrier, reach the peritoneum and migrate to the biliary ducts, where adult worms fully develop. Despite the efforts made to develop new therapeutic and preventive tools, to date, 2022-01-01T00:00:00Z2022 Sep2026-04-08T11:55:10.565Z2025-02-19T02:24:42.32ZS-EPMC95189053611266410.1371/journal.pntd.0010766