biostudies-literatureUnknown7(10)Hedlund BPMost prokaryotes are not available as pure cultures and therefore ineligible for naming under the rules and recommendations of the International Code of Nomenclature of Prokaryotes (ICNP). Here we summarize the development of the SeqCode, a code of nomenclature under which genome sequences serve as nomenclatural types. This code enables valid publication of names of prokaryotes based upon isolate genome, metagenome-assembled genome or single-amplified genome sequences. Otherwise, it is similar to the ICNP with regard to the formation of names and rules of priority. It operates through the SeqCode Registry ( https://seqco.de/ ), a registration portal through which names and nomenclatural types are registered, validated and linked to metadata. We describe the two paths currently available wiNature microbiology1702-1708https://www.ebi.ac.uk/biostudies/studies/S-EPMC9519449biostudies-literatureSeqCode: a nomenclatural code for prokaryotes described from sequence data.PMC9519449Parks DHReysenbach ALSutcliffe ICHedlund BPKonstantinidis KTRossello-Mora RVenter SNProbst AJRodriguez-R LMWhitman WBMurray AEPalmer MChuvochina MHugenholtz PfalseSeqCode: a nomenclatural code for prokaryotes described from sequence data.Most prokaryotes are not available as pure cultures and therefore ineligible for naming under the rules and recommendations of the International Code of Nomenclature of Prokaryotes (ICNP). Here we summarize the development of the SeqCode, a code of nomenclature under which genome sequences serve as nomenclatural types. This code enables valid publication of names of prokaryotes based upon isolate genome, metagenome-assembled genome or single-amplified genome sequences. Otherwise, it is similar to the ICNP with regard to the formation of names and rules of priority. It operates through the SeqCode Registry ( https://seqco.de/ ), a registration portal through which names and nomenclatural types are registered, validated and linked to metadata. We describe the two paths currently available wi2022-01-01T00:00:00Z2022 Oct2026-05-27T19:00:52.19Z2024-12-04T03:29:21.067ZS-EPMC95194493612344210.1038/s41564-022-01214-9