{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zeng T"],"funding":["National Natural Science Foundation of China","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["400"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9519993"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(1)"],"pubmed_abstract":["Elevated extrachromosomal circular DNA (eccDNA) has been reported to accelerate tumor pathogenesis. Although the eccDNA profiles of other tumors have been established, the landscape of the eccDNA of acute myeloid leukemia (AML) has not been revealed. Our study first depicted the eccDNA profile of normal hematopoiesis and AML evolution by exploiting the ATAC-seq and RNA-seq data from nine healthy donors and 12 AML patients, which contained a total of 137 cell samples and 96 RNA-seq samples (including 16 blood cell types of the normal hematopoietic and AML hierarchies). We found the number of eccDNAs generally increased with the evolution of normal hematopoiesis and AML. The ecDNAs and ring chromosomes were found to reappear both in normal hematopoiesis and AML cells. Furthermore, we compare"],"journal":["Cell death discovery"],"pubmed_title":["The landscape of extrachromosomal circular DNA (eccDNA) in the normal hematopoiesis and leukemia evolution."],"pmcid":["PMC9519993"],"funding_grant_id":["U1903117","81500118"],"pubmed_authors":["Lin Q","Xie W","Li J","Cui L","Zeng T","Zhang W","Deng C","Wu Z","Zhu P","Xiao M","Qian T","Huang Z","Zhang Z","Huang W","Chen Y","Fu L"],"additional_accession":[]},"is_claimable":false,"name":"The landscape of extrachromosomal circular DNA (eccDNA) in the normal hematopoiesis and leukemia evolution.","description":"Elevated extrachromosomal circular DNA (eccDNA) has been reported to accelerate tumor pathogenesis. Although the eccDNA profiles of other tumors have been established, the landscape of the eccDNA of acute myeloid leukemia (AML) has not been revealed. Our study first depicted the eccDNA profile of normal hematopoiesis and AML evolution by exploiting the ATAC-seq and RNA-seq data from nine healthy donors and 12 AML patients, which contained a total of 137 cell samples and 96 RNA-seq samples (including 16 blood cell types of the normal hematopoietic and AML hierarchies). We found the number of eccDNAs generally increased with the evolution of normal hematopoiesis and AML. The ecDNAs and ring chromosomes were found to reappear both in normal hematopoiesis and AML cells. Furthermore, we compare","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-27T19:00:00.139Z","creation":"2025-02-19T01:55:43.239Z"},"accession":"S-EPMC9519993","cross_references":{"pubmed":["36171187"],"doi":["10.1038/s41420-022-01189-w"]}}