{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["79(11)"],"submitter":["Bottemanne H"],"pubmed_abstract":["<h4>Importance</h4>Clinical research has shown that persistent negative beliefs maintain depression and that subanesthetic ketamine infusions induce rapid antidepressant responses.<h4>Objective</h4>To evaluate whether ketamine alters belief updating and how such cognitive effects are associated with the clinical effects of ketamine.<h4>Design, setting, and participants</h4>This study used an observational case-control protocol with a mixed-effects design that nested 2 groups by 2 testing time points. Observers were not blinded. Patients with treatment-resistant depression (TRD) and healthy volunteer participants aged 34 to 68 years were included. Patients with TRD were diagnosed with major depressive disorder or bipolar depression, had a Montgomery-Åsberg Depression Rating Scale score grea"],"journal":["JAMA psychiatry"],"pagination":["1124-1132"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9520441"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of Early Ketamine Effects on Belief-Updating Biases in Patients With Treatment-Resistant Depression."],"pmcid":["PMC9520441"],"pubmed_authors":["Claret A","Fossati P","Schmidt L","Bottemanne H","Sharot T","Morlaas O"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of Early Ketamine Effects on Belief-Updating Biases in Patients With Treatment-Resistant Depression.","description":"<h4>Importance</h4>Clinical research has shown that persistent negative beliefs maintain depression and that subanesthetic ketamine infusions induce rapid antidepressant responses.<h4>Objective</h4>To evaluate whether ketamine alters belief updating and how such cognitive effects are associated with the clinical effects of ketamine.<h4>Design, setting, and participants</h4>This study used an observational case-control protocol with a mixed-effects design that nested 2 groups by 2 testing time points. Observers were not blinded. Patients with treatment-resistant depression (TRD) and healthy volunteer participants aged 34 to 68 years were included. Patients with TRD were diagnosed with major depressive disorder or bipolar depression, had a Montgomery-Åsberg Depression Rating Scale score grea","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-18T20:40:06.987Z","creation":"2025-04-07T08:44:35.414Z"},"accession":"S-EPMC9520441","cross_references":{"pubmed":["36169969"],"doi":["10.1001/jamapsychiatry.2022.2996"]}}