{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Reshamwala K"],"pubmed_abstract":["In contrast to the virulent human skin commensal <i>Staphylococcus aureus</i>, which secretes a plethora of toxins, other staphylococci have much reduced virulence. In these species, commonly the only toxins are those of the phenol-soluble modulin (PSM) family. PSMs are species-specific and have only been characterized in a limited number of species. <i>S. xylosus</i> is a usually innocuous commensal on the skin of mice and other mammals. Prompted by reports on the involvement of PSMs in atopic dermatitis (AD) and the isolation of <i>S. xylosus</i> from mice with AD-like symptoms, we here identified and characterized PSMs of <i>S. xylosus</i> with a focus on a potential involvement in AD phenotypes. We found that most clinical <i>S. xylosus</i> strains produce two PSMs, one of the shorter "],"journal":["Frontiers in immunology"],"pagination":["999201"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9520458"],"repository":["biostudies-literature"],"pubmed_title":["Identification and characterization of the pathogenic potential of phenol-soluble modulin toxins in the mouse commensal <i>Staphylococcus xylosus</i>."],"pmcid":["PMC9520458"],"pubmed_authors":["Gozalo AS","Reshamwala K","Zheng Y","Joo HS","Villaruz AE","Bae JS","Nguyen TH","Cheung GYC","Liu R","Elkins WR","Otto M","Hsieh RC"],"additional_accession":[]},"is_claimable":false,"name":"Identification and characterization of the pathogenic potential of phenol-soluble modulin toxins in the mouse commensal <i>Staphylococcus xylosus</i>.","description":"In contrast to the virulent human skin commensal <i>Staphylococcus aureus</i>, which secretes a plethora of toxins, other staphylococci have much reduced virulence. In these species, commonly the only toxins are those of the phenol-soluble modulin (PSM) family. PSMs are species-specific and have only been characterized in a limited number of species. <i>S. xylosus</i> is a usually innocuous commensal on the skin of mice and other mammals. Prompted by reports on the involvement of PSMs in atopic dermatitis (AD) and the isolation of <i>S. xylosus</i> from mice with AD-like symptoms, we here identified and characterized PSMs of <i>S. xylosus</i> with a focus on a potential involvement in AD phenotypes. We found that most clinical <i>S. xylosus</i> strains produce two PSMs, one of the shorter ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T16:17:46.027Z","creation":"2025-04-07T03:22:46.439Z"},"accession":"S-EPMC9520458","cross_references":{"pubmed":["36189200"],"doi":["10.3389/fimmu.2022.999201"]}}