biostudies-literatureTopchu INIDCR NIH HHSU.S. Department of DefenseNational Cancer InstituteNCI NIH HHSU.S. Army Medical Research Acquisition ActivityNational Institutes of HealthProstate Cancer FoundationFeinberg School of MedicineNIH HHS285https://www.ebi.ac.uk/biostudies/studies/S-EPMC9520630biostudies-literatureUnknown79(6)NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain (NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar enzymes mono- and di-methylate H3K36, which contribute to the maintenance of chromatin integrity and regulate the expression of genes that control cell division, apoptosis, DNA repair, and epithelial-mesenchymal transition (EMT). Aberrant expression or mutation of members of the NSD family is associated with developmental defects and the occurrence of some types of cancer. In this review, we discuss the effect of alterations in NSDs on cancer patient's prognosis and response to treatment. We summarize the current understanding of the biological functions of NSD proteins, focusing on their activities and the role in the formation Cellular and molecular life sciences : CMLSThe role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.PMC9520630W81XWH2110487R01 CA227918Translational Bridge AwardP30 CA006927R01CA227918R01 CA2188022017CHAL2008W81XWH-17-1-0405P30 CA0605531P50 DE030707-01P50 DE030707W81XWH-17-1-0578R01 DE027809Golemis EPangeni RPBychkov IMiller SABoumber YYu JTopchu IIzumchenko EKaranicolas JfalseThe role of NSD1, NSD2, and NSD3 histone methyltransferases in solid tumors.NSD1, NSD2, and NSD3 constitute the nuclear receptor-binding SET Domain (NSD) family of histone 3 lysine 36 (H3K36) methyltransferases. These structurally similar enzymes mono- and di-methylate H3K36, which contribute to the maintenance of chromatin integrity and regulate the expression of genes that control cell division, apoptosis, DNA repair, and epithelial-mesenchymal transition (EMT). Aberrant expression or mutation of members of the NSD family is associated with developmental defects and the occurrence of some types of cancer. In this review, we discuss the effect of alterations in NSDs on cancer patient's prognosis and response to treatment. We summarize the current understanding of the biological functions of NSD proteins, focusing on their activities and the role in the formation 2022-01-01T00:00:00Z2022 May2025-04-04T10:21:27.035Z2025-02-19T02:38:08.47ZS-EPMC95206303553281810.1007/s00018-022-04321-2