biostudies-literatureUnknown12(43)Yang KSynthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.RSC advances27877-27880https://www.ebi.ac.uk/biostudies/studies/S-EPMC9520675biostudies-literatureA water-soluble membrane transporter for biologically relevant cations.PMC9520675Yang KLong YHiscock JRHaynes CJEWhite LJLai HYBoles JEHilton KLFfalseA water-soluble membrane transporter for biologically relevant cations.Synthetic ionophores are promising therapeutic targets, yet poor water solubility limits their potential for translation into the clinic. Here we report a water-soluble, supramolecular self-associating amphiphile that functions as a cation uniporter in synthetic vesicle systems, deriving mechanistic insight through planar bilayer patch clamp experiments.2022-01-01T00:00:00Z2022 Sep2025-04-05T13:27:47.454Z2025-02-19T01:30:46.519ZS-EPMC95206753632024610.1039/d2ra05314d