biostudies-literatureUnknown11(1)Yoshida H<h4>Background</h4>Large multicenter studies reporting on the association between the duration of broad-spectrum antimicrobial administration and the detection of multidrug-resistant (MDR) bacteria in the intensive care unit (ICU) are scarce. We evaluated the impact of broad-spectrum antimicrobial therapy for more than 72 h on the detection of MDR bacteria using the data from Japanese patients enrolled in the DIANA study.<h4>Methods</h4>We analyzed the data of ICU patients in the DIANA study (a multicenter international observational cohort study from Japan). Patients who received empirical antimicrobials were divided into a broad-spectrum antimicrobial group and a narrow-spectrum antimicrobial group, based on whether they received broad-spectrum antimicrobials for more or less than 72 h, Antimicrobial resistance and infection control119https://www.ebi.ac.uk/biostudies/studies/S-EPMC9520832biostudies-literatureUse of broad-spectrum antimicrobials for more than 72 h and the detection of multidrug-resistant bacteria in Japanese intensive care units: a multicenter retrospective cohort study.PMC9520832Suzuki TKida YKatayama SFujitani SKameda SNashiki HShibata MKawagishi TKobayashi ADe Bus LHashimoto SHashimoto HTanaka CMotohashi THara YDIANA Study Japanese groupInoue MYoshida HShindo SHashi HKomuro TKanamoto MDe Waele JKawano YTakaba AFujiwara SKuriyama AFujita YfalseUse of broad-spectrum antimicrobials for more than 72 h and the detection of multidrug-resistant bacteria in Japanese intensive care units: a multicenter retrospective cohort study.<h4>Background</h4>Large multicenter studies reporting on the association between the duration of broad-spectrum antimicrobial administration and the detection of multidrug-resistant (MDR) bacteria in the intensive care unit (ICU) are scarce. We evaluated the impact of broad-spectrum antimicrobial therapy for more than 72 h on the detection of MDR bacteria using the data from Japanese patients enrolled in the DIANA study.<h4>Methods</h4>We analyzed the data of ICU patients in the DIANA study (a multicenter international observational cohort study from Japan). Patients who received empirical antimicrobials were divided into a broad-spectrum antimicrobial group and a narrow-spectrum antimicrobial group, based on whether they received broad-spectrum antimicrobials for more or less than 72 h, 2022-01-01T00:00:00Z2022 Sep2026-05-27T19:12:30.137Z2025-05-18T12:49:08.983ZS-EPMC95208323617594810.1186/s13756-022-01146-3