{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen T"],"funding":["Natural Science Foundation of Tianjin City","National Natural Science Foundation of China"],"pagination":["335"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9520944"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["<h4>Background</h4>Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases. The dysregulation of liver sinusoidal endothelial cell (LSEC) phenotype is a critical early event in the fibrotic process. However, the biological function of lncRNAs in LSEC still remains unclear.<h4>Methods</h4>The expression level of lncRNA Airn was evaluated in both human fibrotic livers and serums, as well as mouse fibrotic livers. Gain- and loss-of-function experiments were performed to detect the effect of Airn on LSEC differentiation and hepatic stellate cell (HSC) activation in liver fibrosis. Furthermore, RIP, RNA pull-down-immunoblotting, and ChIP experiments were performed to explore the underlying mechanisms of Airn.<h4>Results</h4>We have identified Airn was s"],"journal":["BMC medicine"],"pubmed_title":["LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway."],"pmcid":["PMC9520944"],"funding_grant_id":["81971331","81870429","82170630","32171125","81800542","19JCZDJC36700"],"pubmed_authors":["Zhang K","Hu Z","Han X","Du X","Yao Q","Shi Z","Han T","Zhao Y","Meng X","Zhao S","Zheng L","Lin H","Hong W","Chen T"],"additional_accession":[]},"is_claimable":false,"name":"LncRNA Airn maintains LSEC differentiation to alleviate liver fibrosis via the KLF2-eNOS-sGC pathway.","description":"<h4>Background</h4>Long noncoding RNAs (lncRNAs) have emerged as important regulators in a variety of human diseases. The dysregulation of liver sinusoidal endothelial cell (LSEC) phenotype is a critical early event in the fibrotic process. However, the biological function of lncRNAs in LSEC still remains unclear.<h4>Methods</h4>The expression level of lncRNA Airn was evaluated in both human fibrotic livers and serums, as well as mouse fibrotic livers. Gain- and loss-of-function experiments were performed to detect the effect of Airn on LSEC differentiation and hepatic stellate cell (HSC) activation in liver fibrosis. Furthermore, RIP, RNA pull-down-immunoblotting, and ChIP experiments were performed to explore the underlying mechanisms of Airn.<h4>Results</h4>We have identified Airn was s","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-27T19:01:01.087Z","creation":"2025-02-19T01:55:45.916Z"},"accession":"S-EPMC9520944","cross_references":{"pubmed":["36171606"],"doi":["10.1186/s12916-022-02523-w"]}}