biostudies-literatureZhang YScience and Technology Innovation Plan Of Shanghai Science and Technology CommissionNational Natural Science Foundation of China990894https://www.ebi.ac.uk/biostudies/studies/S-EPMC9521709biostudies-literatureUnknown10<h4>Background</h4>Fluoroquinolones (FQs) are the most important second-line anti-tuberculosis (anti-TB) drugs, primarily used for the treatment of multidrug- or rifampicin-resistant TB (MDR/RR-TB). However, FQs are also commonly used to treat other bacterial infections. There are few published data on the rates of FQ resistance among rifampicin-susceptible TB.<h4>Methods</h4>We used whole-genome sequencing (WGS) to determine the prevalence of FQ resistance among rifampicin-susceptible TB in a rural district of Shanghai. This was a population-based retrospective study of all culture-positive pulmonary TB patients diagnosed in the Chongming district of Shanghai, China during 2009-2018.<h4>Results</h4>The rate of FQ resistance was 8.4% (29/345) among TB, 6.2% (20/324) among rifampicin-suscepFrontiers in public healthWhole-genome sequencing for surveillance of fluoroquinolone resistance in rifampicin-susceptible tuberculosis in a rural district of Shanghai: A 10-year retrospective study.PMC952170921DZ220240081872679Jiang YLi JYu CZhang YPan QShen XfalseWhole-genome sequencing for surveillance of fluoroquinolone resistance in rifampicin-susceptible tuberculosis in a rural district of Shanghai: A 10-year retrospective study.<h4>Background</h4>Fluoroquinolones (FQs) are the most important second-line anti-tuberculosis (anti-TB) drugs, primarily used for the treatment of multidrug- or rifampicin-resistant TB (MDR/RR-TB). However, FQs are also commonly used to treat other bacterial infections. There are few published data on the rates of FQ resistance among rifampicin-susceptible TB.<h4>Methods</h4>We used whole-genome sequencing (WGS) to determine the prevalence of FQ resistance among rifampicin-susceptible TB in a rural district of Shanghai. This was a population-based retrospective study of all culture-positive pulmonary TB patients diagnosed in the Chongming district of Shanghai, China during 2009-2018.<h4>Results</h4>The rate of FQ resistance was 8.4% (29/345) among TB, 6.2% (20/324) among rifampicin-suscep2022-01-01T00:00:00Z20222026-06-21T03:10:24.759Z2025-02-19T03:24:13.384ZS-EPMC95217093618769410.3389/fpubh.2022.990894