biostudies-literatureGuo HFundamental Research Funds for the Central UniversitiesNICHD NIH HHSNational Natural Science Foundation of ChinaLiaoning Revitalization Talents ProgramNational Science Foundation2102724https://www.ebi.ac.uk/biostudies/studies/S-EPMC9521812biostudies-literatureUnknown31(29)Injured peripheral nerves typically exhibit unsatisfactory and incomplete functional outcomes, and there are no clinically approved therapies for improving regeneration. Post-operative electrical stimulation (ES) increases axon regrowth, but practical challenges from the cost of extended operating room time to the risks and pitfalls associated with transcutaneous wire placement have prevented broad clinical adoption. This study presents a possible solution in the form of advanced bioresorbable materials for thin, flexible, wireless implant that provides precisely controlled ES of the injured nerve for a brief time in the immediate post-operative period. Afterward, rapid, complete and safe modes of bioresorption naturally and quickly eliminate all of the constituent materials in their entirAdvanced functional materialsAdvanced Materials in Wireless, Implantable Electrical Stimulators That Offer Rapid Rates of Bioresorption for Peripheral Axon Regeneration.PMC952181212072057R03 HD101090DUT20RC(3)032XLYC180712612022209CMMI163544311972103DMR‐1720139Koo JFranz CKMeda RXie ZMurthy NKLi RQiao ZBai WHuang YGuo HJanes LED'Andrea DZhao JSong ZChoi YSJordan SWXu YRogers JAfalseAdvanced Materials in Wireless, Implantable Electrical Stimulators That Offer Rapid Rates of Bioresorption for Peripheral Axon Regeneration.Injured peripheral nerves typically exhibit unsatisfactory and incomplete functional outcomes, and there are no clinically approved therapies for improving regeneration. Post-operative electrical stimulation (ES) increases axon regrowth, but practical challenges from the cost of extended operating room time to the risks and pitfalls associated with transcutaneous wire placement have prevented broad clinical adoption. This study presents a possible solution in the form of advanced bioresorbable materials for thin, flexible, wireless implant that provides precisely controlled ES of the injured nerve for a brief time in the immediate post-operative period. Afterward, rapid, complete and safe modes of bioresorption naturally and quickly eliminate all of the constituent materials in their entir2021-01-01T00:00:00Z2021 Jul2025-04-26T15:32:46.58Z2024-11-12T21:06:57.974ZS-EPMC95218123618917210.1002/adfm.202102724