{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lai Y"],"funding":["National Heart, Lung, and Blood Institute","NHLBI NIH HHS","US Department of Veterans Affairs","CSRD VA"],"pagination":["383-393"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9522923"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(4)"],"pubmed_abstract":["<h4>Background</h4>One hallmark of sepsis is the reduced number of lymphocytes, termed lymphopenia, that occurs from decreased lymphocyte proliferation or increased cell death contributing to immune suppression. Histone modification enzymes regulate immunity by their epigenetic and non-epigenetic functions; however, the role of these enzymes in lymphopenia remains elusive.<h4>Methods</h4>We used molecular biological approaches to investigate the high expression and function of a chromatin modulator protein arginine N-methyltransferase 4 (PRMT4)/coactivator-associated arginine methyltransferase 1 in human samples from septic patients and cellular and animal septic models.<h4>Results</h4>We identified that PRMT4 is elevated systemically in septic patients and experimental sepsis. Gram-negati"],"journal":["Thorax"],"pubmed_title":["Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis."],"pmcid":["PMC9522923"],"funding_grant_id":["HL125435","K23 HL139987","HL143285","HL142997","I01 CX000105","R01 HL097376","HL136143","R01 HL136143","K24 HL143285","R01 HL125435","HL097376","R01 HL142997","HL142084","5I01CX000105-06","P01 HL114453","R01 HL098174","R01 HL142084","HL081784","R01 HL096376","CX001048","R01 HL149719","R01 HL081784","I01 CX001048","HL098174","HL096376"],"pubmed_authors":["Lee JS","Mallmapalli RK","Lai Y","Li X","Chen K","Kitsios G","Li T","Zhang Y","Nouraie M","McVerry BJ","Zou C","Nyunoya T"],"additional_accession":[]},"is_claimable":false,"name":"Protein arginine N-methyltransferase 4 (PRMT4) contributes to lymphopenia in experimental sepsis.","description":"<h4>Background</h4>One hallmark of sepsis is the reduced number of lymphocytes, termed lymphopenia, that occurs from decreased lymphocyte proliferation or increased cell death contributing to immune suppression. Histone modification enzymes regulate immunity by their epigenetic and non-epigenetic functions; however, the role of these enzymes in lymphopenia remains elusive.<h4>Methods</h4>We used molecular biological approaches to investigate the high expression and function of a chromatin modulator protein arginine N-methyltransferase 4 (PRMT4)/coactivator-associated arginine methyltransferase 1 in human samples from septic patients and cellular and animal septic models.<h4>Results</h4>We identified that PRMT4 is elevated systemically in septic patients and experimental sepsis. Gram-negati","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Apr","modification":"2026-07-14T17:15:48.984Z","creation":"2026-06-21T03:13:05.7Z"},"accession":"S-EPMC9522923","cross_references":{"pubmed":["35354645"],"doi":["10.1136/thoraxjnl-2021-217526"]}}