{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Geng B"],"funding":["China Postdoctoral Science Foundation","Science and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission)","National Natural Science Foundation of China (National Science Foundation of China)"],"pagination":["5735"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9523047"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for imaging guided sonodynamic therapy (SDT). It is challenging, however, to realize a single material that is simultaneously endowed with both NIR emitting and sonodynamic activities. Herein, we report the design of a class of NIR-emitting sonosensitizers from a NIR phosphorescent carbon dot (CD) material with a narrow bandgap (1.62 eV) and long-lived excited triplet states (11.4 μs), two of which can enhance SDT as thermodynamically and dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs are identified as bipolar quantum dots containing both p- and n-type surface functionalization regions that can drive spatial separation "],"journal":["Nature communications"],"pubmed_title":["Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy."],"pmcid":["PMC9523047"],"funding_grant_id":["22177067","2020M681267","22108168","22ZR1424000","22278262","12175142"],"pubmed_authors":["Shen L","Li Y","Feng L","Geng B","Pan D","Hu J","Feng S"],"additional_accession":[]},"is_claimable":false,"name":"Near-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy.","description":"Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for imaging guided sonodynamic therapy (SDT). It is challenging, however, to realize a single material that is simultaneously endowed with both NIR emitting and sonodynamic activities. Herein, we report the design of a class of NIR-emitting sonosensitizers from a NIR phosphorescent carbon dot (CD) material with a narrow bandgap (1.62 eV) and long-lived excited triplet states (11.4 μs), two of which can enhance SDT as thermodynamically and dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs are identified as bipolar quantum dots containing both p- and n-type surface functionalization regions that can drive spatial separation ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-21T18:52:59.156Z","creation":"2025-02-19T01:22:16.891Z"},"accession":"S-EPMC9523047","cross_references":{"pubmed":["36175446"],"doi":["10.1038/s41467-022-33474-8"]}}