biostudies-literatureGeng BChina Postdoctoral Science FoundationScience and Technology Commission of Shanghai Municipality (Shanghai Municipal Science and Technology Commission)National Natural Science Foundation of China (National Science Foundation of China)5735https://www.ebi.ac.uk/biostudies/studies/S-EPMC9523047biostudies-literatureUnknown13(1)Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for imaging guided sonodynamic therapy (SDT). It is challenging, however, to realize a single material that is simultaneously endowed with both NIR emitting and sonodynamic activities. Herein, we report the design of a class of NIR-emitting sonosensitizers from a NIR phosphorescent carbon dot (CD) material with a narrow bandgap (1.62 eV) and long-lived excited triplet states (11.4 μs), two of which can enhance SDT as thermodynamically and dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs are identified as bipolar quantum dots containing both p- and n-type surface functionalization regions that can drive spatial separation Nature communicationsNear-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy.PMC9523047221770672020M6812672210816822ZR14240002227826212175142Shen LLi YFeng LGeng BPan DHu JFeng SfalseNear-infrared phosphorescent carbon dots for sonodynamic precision tumor therapy.Theranostic sonosensitizers with combined sonodynamic and near infrared (NIR) imaging modes are required for imaging guided sonodynamic therapy (SDT). It is challenging, however, to realize a single material that is simultaneously endowed with both NIR emitting and sonodynamic activities. Herein, we report the design of a class of NIR-emitting sonosensitizers from a NIR phosphorescent carbon dot (CD) material with a narrow bandgap (1.62 eV) and long-lived excited triplet states (11.4 μs), two of which can enhance SDT as thermodynamically and dynamically favorable factors under low-intensity ultrasound irradiation, respectively. The NIR-phosphorescent CDs are identified as bipolar quantum dots containing both p- and n-type surface functionalization regions that can drive spatial separation 2022-01-01T00:00:00Z2022 Sep2025-04-21T18:52:59.156Z2025-02-19T01:22:16.891ZS-EPMC95230473617544610.1038/s41467-022-33474-8