biostudies-literatureUnknown13Li SCKidney cancer is one of the most common urological cancers worldwide, and kidney renal clear cell cancer (KIRC) is the major histologic subtype. Our previous study found that von-Hippel Lindau (VHL) gene mutation, the dominant reason for sporadic KIRC and hereditary kidney cancer-VHL syndrome, could affect VHL disease-related cancers development by inducing telomere shortening. However, the prognosis role of telomere-related genes in kidney cancer has not been well discussed. In this study, we obtained the telomere-related genes (TRGs) from TelNet. We obtained the clinical information and TRGs expression status of kidney cancer patients in The Cancer Genome Atlas (TCGA) database, The International Cancer Genome Consortium (ICGC) database, and the Clinical Proteomic Tumor Analysis ConsortiuFrontiers in immunology975057https://www.ebi.ac.uk/biostudies/studies/S-EPMC9523360biostudies-literatureTelomere-related gene risk model for prognosis and drug treatment efficiency prediction in kidney cancer.PMC9523360Yang JJJia ZKLi SCNing XHfalseTelomere-related gene risk model for prognosis and drug treatment efficiency prediction in kidney cancer.Kidney cancer is one of the most common urological cancers worldwide, and kidney renal clear cell cancer (KIRC) is the major histologic subtype. Our previous study found that von-Hippel Lindau (VHL) gene mutation, the dominant reason for sporadic KIRC and hereditary kidney cancer-VHL syndrome, could affect VHL disease-related cancers development by inducing telomere shortening. However, the prognosis role of telomere-related genes in kidney cancer has not been well discussed. In this study, we obtained the telomere-related genes (TRGs) from TelNet. We obtained the clinical information and TRGs expression status of kidney cancer patients in The Cancer Genome Atlas (TCGA) database, The International Cancer Genome Consortium (ICGC) database, and the Clinical Proteomic Tumor Analysis Consortiu2022-01-01T00:00:00Z20222025-04-22T03:46:40.812Z2025-04-05T20:44:49.463ZS-EPMC95233603618931210.3389/fimmu.2022.975057