biostudies-literaturePeng XBLRD VANCATS NIH HHSNHLBI NIH HHS1314-1322https://www.ebi.ac.uk/biostudies/studies/S-EPMC9523490biostudies-literatureUnknown209(7)Postviral bacterial infections are a major health care challenge in coronavirus infections, including COVID-19; however, the coronavirus-specific mechanisms of increased host susceptibility to secondary infections remain unknown. In humans, coronaviruses, including SARS-CoV-2, infect lung immune cells, including alveolar macrophages, a phenotype poorly replicated in mouse models of SARS-CoV-2. To overcome this, we used a mouse model of native murine β-coronavirus that infects both immune and structural cells to investigate coronavirus-enhanced susceptibility to bacterial infections. Our data show that coronavirus infection impairs the host ability to clear invading bacterial pathogens and potentiates lung tissue damage in mice. Mechanistically, coronavirus limits the bacterial killing abilJournal of immunology (Baltimore, Md. : 1950)Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.PMC9523490I01 BX004661T32 HL007778UL1 TR001863R01 HL126094Peng XAudia JPKorde AMankowski MCAgaronyan KKim JWang LSharma LLiu XIshibe STakyar SSVoth SHabet VChangTian XGupta GKang MJCai YWilen CBDela Cruz CSShin HJCompton SfalseCoronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction.Postviral bacterial infections are a major health care challenge in coronavirus infections, including COVID-19; however, the coronavirus-specific mechanisms of increased host susceptibility to secondary infections remain unknown. In humans, coronaviruses, including SARS-CoV-2, infect lung immune cells, including alveolar macrophages, a phenotype poorly replicated in mouse models of SARS-CoV-2. To overcome this, we used a mouse model of native murine β-coronavirus that infects both immune and structural cells to investigate coronavirus-enhanced susceptibility to bacterial infections. Our data show that coronavirus infection impairs the host ability to clear invading bacterial pathogens and potentiates lung tissue damage in mice. Mechanistically, coronavirus limits the bacterial killing abil2022-01-01T00:00:00Z2022 Oct2025-04-04T21:10:02.936Z2025-04-04T21:10:02.936ZS-EPMC95234903616519610.4049/jimmunol.2200198