{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Juarez I"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","NIAMS NIH HHS","Universidad Complutense de Madrid"],"pagination":["906355"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9523749"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Cytotoxic CD8 T cells are crucial for the host antigen-specific immune response to viral pathogens. Here we report the identification of an essential role for the serine/arginine-rich splicing factor (SRSF) 1 in CD8 T cell homeostasis and function. Specifically, SRSF1 is necessary for the maintenance of normal CD8 T lymphocyte numbers in the lymphoid compartment, and for the proliferative capacity and cytotoxic function of CD8 T cells. Furthermore, SRSF1 is required for antigen-specific IFN-γ cytokine responses in a viral infection challenge in mice. Transcriptomics analyses of Srsf1-deficient T cells reveal that SRSF1 controls proliferation, MAP kinase signaling and IFN signaling pathways. Mechanistically, SRSF1 controls the expression and activity of the Mnk2/p38-MAPK axis at the molecular level. Our findings reveal previously unrecognized roles for SRSF1 in the physiology and function of cytotoxic CD8 T lymphocytes and a potential molecular mechanism in viral immunopathogenesis."],"journal":["Frontiers in immunology"],"pubmed_title":["Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity."],"pmcid":["PMC9523749"],"funding_grant_id":["R01 AR068974"],"pubmed_authors":["Su S","Teijaro JR","Herbert ZT","Juarez I","Moulton VR"],"additional_accession":[]},"is_claimable":false,"name":"Splicing factor SRSF1 is essential for CD8 T cell function and host antigen-specific viral immunity.","description":"Cytotoxic CD8 T cells are crucial for the host antigen-specific immune response to viral pathogens. Here we report the identification of an essential role for the serine/arginine-rich splicing factor (SRSF) 1 in CD8 T cell homeostasis and function. Specifically, SRSF1 is necessary for the maintenance of normal CD8 T lymphocyte numbers in the lymphoid compartment, and for the proliferative capacity and cytotoxic function of CD8 T cells. Furthermore, SRSF1 is required for antigen-specific IFN-γ cytokine responses in a viral infection challenge in mice. Transcriptomics analyses of Srsf1-deficient T cells reveal that SRSF1 controls proliferation, MAP kinase signaling and IFN signaling pathways. Mechanistically, SRSF1 controls the expression and activity of the Mnk2/p38-MAPK axis at the molecular level. Our findings reveal previously unrecognized roles for SRSF1 in the physiology and function of cytotoxic CD8 T lymphocytes and a potential molecular mechanism in viral immunopathogenesis.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T18:19:52.407Z","creation":"2025-04-05T22:22:12.599Z"},"accession":"S-EPMC9523749","cross_references":{"pubmed":["36189299"],"doi":["10.3389/fimmu.2022.906355"]}}