{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Cobos C"],"pubmed_abstract":["A decline in the prevalence of parasites such as hookworms appears to be correlated with the rise in non-communicable inflammatory conditions in people from high- and middle-income countries. This correlation has led to studies that have identified proteins produced by hookworms that can suppress inflammatory bowel disease (IBD) and asthma in animal models. Hookworms secrete a family of abundant netrin-domain containing proteins referred to as AIPs (Anti-Inflammatory Proteins), but there is no information on the structure-function relationships. Here we have applied a downsizing approach to the hookworm AIPs to derive peptides of 20 residues or less, some of which display anti-inflammatory effects when co-cultured with human peripheral blood mononuclear cells and oral therapeutic activity in a chemically induced mouse model of acute colitis. Our results indicate that a conserved helical region is responsible, at least in part, for the anti-inflammatory effects. This helical region has potential in the design of improved leads for treating IBD and possibly other inflammatory conditions."],"journal":["Frontiers in medicine"],"pagination":["934852"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9524151"],"repository":["biostudies-literature"],"pubmed_title":["Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells."],"pmcid":["PMC9524151"],"pubmed_authors":["Field MA","Daly NL","Giacomin PR","Navarro S","Loukas A","Ryan RYM","Ruscher R","Ratnatunga CN","Pickering DA","Wilson DT","Eichenberger RM","Jones L","Zhao G","Cobos C","Miles JJ","Bansal PS"],"additional_accession":[]},"is_claimable":false,"name":"Peptides derived from hookworm anti-inflammatory proteins suppress inducible colitis in mice and inflammatory cytokine production by human cells.","description":"A decline in the prevalence of parasites such as hookworms appears to be correlated with the rise in non-communicable inflammatory conditions in people from high- and middle-income countries. This correlation has led to studies that have identified proteins produced by hookworms that can suppress inflammatory bowel disease (IBD) and asthma in animal models. Hookworms secrete a family of abundant netrin-domain containing proteins referred to as AIPs (Anti-Inflammatory Proteins), but there is no information on the structure-function relationships. Here we have applied a downsizing approach to the hookworm AIPs to derive peptides of 20 residues or less, some of which display anti-inflammatory effects when co-cultured with human peripheral blood mononuclear cells and oral therapeutic activity in a chemically induced mouse model of acute colitis. Our results indicate that a conserved helical region is responsible, at least in part, for the anti-inflammatory effects. This helical region has potential in the design of improved leads for treating IBD and possibly other inflammatory conditions.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T15:56:04.817Z","creation":"2025-04-04T12:46:14.995Z"},"accession":"S-EPMC9524151","cross_references":{"pubmed":["36186812"],"doi":["10.3389/fmed.2022.934852"]}}