biostudies-literatureMishra ABLRD VABritish Heart FoundationNIA NIH HHSNHLBI NIH HHSLundbeck FoundationCSRD VANIDDK NIH HHSMedical Research CouncilNHGRI NIH HHSNational Institute for Health Research (NIHR)NLM NIH HHSNINDS NIH HHSWellcome Trust115-123https://www.ebi.ac.uk/biostudies/studies/S-EPMC9524349biostudies-literatureUnknown611(7934)Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry^1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were NatureStroke genetics informs drug discovery and risk prediction across ancestries.PMC9524349R01 AG015819R01 NS114045CH/1996001/9454RG/18/13/33946G0300622K08 HL153950HDR-9004MC_UU_12026/2P30 AG072975MC_EX_G0801669RG/13/13/30194I01 BX004821MC_PC_12027FS/14/55/30806R01 LM010685MC_UU_00017/1MC_PC_12029MC_PC_12028U01 NS041588MR/S004130/1MC_U137686851MC_PC_14135MC_U137686854IK2 CX001780212946/Z/18/ZP30 AG010161R01 DK084350NIHR202339U01 HG010273R278-2018-804CH/12/2/29428R01 AG017917R01 HL105756MC_PC_13049Uitterlinden AGKoido MRoshchupkin GVSacco RLChen PHde Laat KFButterworth ASPRECISE4Q ConsortiumKristoffersen ESMatsuda KDiaz-Navarro RKamatani YHolliday EGWolfe CDAMorisaki TMilani LJenkins CAkpa OSobrino TXu HStrauch KLuijckx GJWennberg Pvan 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VInternational Stroke Genetics Consortium (ISGC)Rissanen ILDelgado PBrouwers PJAMLopez-Cancio ERibo MTakai TSloane KLSanghera DKLorentzen EHeuch IKappelle LJYonova-Doing EPsaty BMHeuschmann PUJukema JWSarin APMaguire JKoudstaal PJFerreira LEPrats-Sanchez LParodi LLiu YMNederkoorn PJMosley THWiggins KLRost NSMinegishi NAnderson CDO'Donnell MJTsugane STzourio CGrabe HJAdebajo OJMEGASTROKE ConsortiumKabrhel CTiwari HKSarju REsko THagen KVibo RHe JWoo DLiman TMuino EReiner ABuring JEFurie KLBartz TMvan Norden AGWOvbiagele BLemmons RBeiser ASHe YLangefeld CDObiako RGretarsdottir SPankow JSLin KChong MRJackson RDArenillas JFCullell NSasaki MSchmidt COThomassen JQGiulianini FAkinyemi JLee THMillwood IYden Hoed MChowhan AGiese AKAkinyemi RHansen JBSatoh MSatizabal CLLioutas VMeschia JFCain AHeit JARannikmae KBoncoraglio GBCheng YCKleindorfer DOWahab KYamaji TINVENT Consortiumvan Setten JGallego-Fabrega CTanislav CKnol MJRabionet RBis JCKalra LKomolafe MBevan SParati EAHyacinth HILe Grand 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FSMartinsen AEKim YJde Kort PLJensen GBDutch Parelsnoer Initiative (PSI) Cerebrovascular Disease Study GroupGhanbari MCushman MVerma SSDuan QAgunloye ALangenberg CArmasu SMMagnusson PKLongstreth WTSeshadri SSerrano-Heras GRosand JOkada YEstonian BiobankLindstrom SKumar ATanno KSkogholt AHfalseStroke genetics informs drug discovery and risk prediction across ancestries.Previous genome-wide association studies (GWASs) of stroke - the second leading cause of death worldwide - were conducted predominantly in populations of European ancestry^1,2. Here, in cross-ancestry GWAS meta-analyses of 110,182 patients who have had a stroke (five ancestries, 33% non-European) and 1,503,898 control individuals, we identify association signals for stroke and its subtypes at 89 (61 new) independent loci: 60 in primary inverse-variance-weighted analyses and 29 in secondary meta-regression and multitrait analyses. On the basis of internal cross-ancestry validation and an independent follow-up in 89,084 additional cases of stroke (30% non-European) and 1,013,843 control individuals, 87% of the primary stroke risk loci and 60% of the secondary stroke risk loci were 2022-01-01T00:00:00Z2022 Nov2026-05-31T16:05:17.504Z2025-02-19T01:27:39.64ZS-EPMC95243493618079510.1038/s41586-022-05165-3