{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alcamo AM"],"funding":["NIDDK NIH HHS","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["593-605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9524404"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(8)"],"pubmed_abstract":["<h4>Objectives</h4>To compare outcomes associated with timing-early versus late-of any neurologic dysfunction during pediatric sepsis.<h4>Design</h4>Secondary analysis of a cross-sectional point prevalence study.<h4>Setting</h4>A total of 128 PICUs in 26 countries.<h4>Patients</h4>Less than 18 years with severe sepsis on 5 separate days (2013-2014).<h4>Interventions</h4>None.<h4>Measurements and main results</h4>Patients were categorized as having either no neurologic dysfunction or neurologic dysfunction (i.e., present at or after sepsis recognition), which was defined as Glasgow Coma Scale score less than 5 and/or fixed dilated pupils. Our primary outcome was death or new moderate disability (i.e., Pediatric Overall [or Cerebral] Performance Category score ≥3 and change ≥1 from baseline)"],"journal":["Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies"],"pubmed_title":["Outcomes Associated With Timing of Neurologic Dysfunction Onset Relative to Pediatric Sepsis Recognition."],"pmcid":["PMC9524404"],"funding_grant_id":["K23 DK119463"],"pubmed_authors":["Alcamo AM","Tang SF","Kirschen MP","Fitzgerald JC","Thomas NJ","Sepsis Prevalence, Outcomes and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network","Loftis LL","Nett ST","Weiss SL","Nadkarni VM"],"additional_accession":[]},"is_claimable":false,"name":"Outcomes Associated With Timing of Neurologic Dysfunction Onset Relative to Pediatric Sepsis Recognition.","description":"<h4>Objectives</h4>To compare outcomes associated with timing-early versus late-of any neurologic dysfunction during pediatric sepsis.<h4>Design</h4>Secondary analysis of a cross-sectional point prevalence study.<h4>Setting</h4>A total of 128 PICUs in 26 countries.<h4>Patients</h4>Less than 18 years with severe sepsis on 5 separate days (2013-2014).<h4>Interventions</h4>None.<h4>Measurements and main results</h4>Patients were categorized as having either no neurologic dysfunction or neurologic dysfunction (i.e., present at or after sepsis recognition), which was defined as Glasgow Coma Scale score less than 5 and/or fixed dilated pupils. Our primary outcome was death or new moderate disability (i.e., Pediatric Overall [or Cerebral] Performance Category score ≥3 and change ≥1 from baseline)","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-04T20:06:57.563Z","creation":"2025-04-04T20:06:57.563Z"},"accession":"S-EPMC9524404","cross_references":{"pubmed":["36165937"],"doi":["10.1097/PCC.0000000000002979","10.1097/pcc.0000000000002979"]}}