biostudies-literatureAlcamo AMNIDDK NIH HHSNational Institute for Health Research (NIHR)Wellcome Trust593-605https://www.ebi.ac.uk/biostudies/studies/S-EPMC9524404biostudies-literatureUnknown23(8)<h4>Objectives</h4>To compare outcomes associated with timing-early versus late-of any neurologic dysfunction during pediatric sepsis.<h4>Design</h4>Secondary analysis of a cross-sectional point prevalence study.<h4>Setting</h4>A total of 128 PICUs in 26 countries.<h4>Patients</h4>Less than 18 years with severe sepsis on 5 separate days (2013-2014).<h4>Interventions</h4>None.<h4>Measurements and main results</h4>Patients were categorized as having either no neurologic dysfunction or neurologic dysfunction (i.e., present at or after sepsis recognition), which was defined as Glasgow Coma Scale score less than 5 and/or fixed dilated pupils. Our primary outcome was death or new moderate disability (i.e., Pediatric Overall [or Cerebral] Performance Category score ≥3 and change ≥1 from baseline)Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care SocietiesOutcomes Associated With Timing of Neurologic Dysfunction Onset Relative to Pediatric Sepsis Recognition.PMC9524404K23 DK119463Alcamo AMTang SFKirschen MPFitzgerald JCThomas NJSepsis Prevalence, Outcomes and Therapies (SPROUT) Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) NetworkLoftis LLNett STWeiss SLNadkarni VMfalseOutcomes Associated With Timing of Neurologic Dysfunction Onset Relative to Pediatric Sepsis Recognition.<h4>Objectives</h4>To compare outcomes associated with timing-early versus late-of any neurologic dysfunction during pediatric sepsis.<h4>Design</h4>Secondary analysis of a cross-sectional point prevalence study.<h4>Setting</h4>A total of 128 PICUs in 26 countries.<h4>Patients</h4>Less than 18 years with severe sepsis on 5 separate days (2013-2014).<h4>Interventions</h4>None.<h4>Measurements and main results</h4>Patients were categorized as having either no neurologic dysfunction or neurologic dysfunction (i.e., present at or after sepsis recognition), which was defined as Glasgow Coma Scale score less than 5 and/or fixed dilated pupils. Our primary outcome was death or new moderate disability (i.e., Pediatric Overall [or Cerebral] Performance Category score ≥3 and change ≥1 from baseline)2022-01-01T00:00:00Z2022 Aug2025-04-04T20:06:57.563Z2025-04-04T20:06:57.563ZS-EPMC95244043616593710.1097/PCC.000000000000297910.1097/pcc.0000000000002979