{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(9)"],"submitter":["Myers F"],"pubmed_abstract":["The COVID-19 pandemic has highlighted the need for broader access to molecular diagnostics. Colorimetric isothermal nucleic acid amplification assays enable simplified instrumentation over more conventional PCR diagnostic assays and, as such, represent a promising approach for addressing this need. In particular, colorimetric LAMP (loop-mediated isothermal amplification) has received a great deal of interest recently. However, there do not currently exist robust instruments for performing these kinds of assays in high throughput with real-time readout of amplification signals. To address this need, we developed LARI, the LAMP Assay Reader Instrument. We have deployed over 50 LARIs for routine use in R&D and production environments, with over 12,000 assays run to date. In this paper, we pre"],"journal":["PloS one"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9524685"],"repository":["biostudies-literature"],"pubmed_title":["A robust, low-cost instrument for real-time colorimetric isothermal nucleic acid amplification"],"pmcid":["PMC9524685"],"pubmed_authors":["El Khaja R","McGee M","Chatterjee T","Moffatt B","Marwaha G","Myers F","Mitra D"],"additional_accession":[]},"is_claimable":false,"name":"A robust, low-cost instrument for real-time colorimetric isothermal nucleic acid amplification","description":"The COVID-19 pandemic has highlighted the need for broader access to molecular diagnostics. Colorimetric isothermal nucleic acid amplification assays enable simplified instrumentation over more conventional PCR diagnostic assays and, as such, represent a promising approach for addressing this need. In particular, colorimetric LAMP (loop-mediated isothermal amplification) has received a great deal of interest recently. However, there do not currently exist robust instruments for performing these kinds of assays in high throughput with real-time readout of amplification signals. To address this need, we developed LARI, the LAMP Assay Reader Instrument. We have deployed over 50 LARIs for routine use in R&D and production environments, with over 12,000 assays run to date. In this paper, we pre","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-04T12:04:34.706Z","creation":"2025-02-19T00:23:47.788Z"},"accession":"S-EPMC9524685","cross_references":{}}