biostudies-literatureErlandson KMKOWA PharmaceuticalsNational Institute of Allergy and Infectious DiseasesNIDDK NIH HHSNIA NIH HHSNIAID NIH HHSStatistical and Data Management CenterNHLBI NIH HHSLeadership and Operations CenterClinical Coordinating CenterNational Institutes of HealthGilead SciencesViiV Healthcare1154-1163https://www.ebi.ac.uk/biostudies/studies/S-EPMC9525090biostudies-literatureUnknown75(7)<h4>Background</h4>We sought to explore multinational differences in functional status by global burden of disease (GBD) regions in the REPRIEVE cohort.<h4>Methods</h4>REPRIEVE is a prospective, double-blind, randomized, placebo-controlled, multicenter, phase III primary cardiovascular prevention study of pitavastatin calcium vs placebo among people with human immunodeficiency virus (HIV, PWH) ages 40-75 on antiretroviral therapy (ART). GBD super regions were defined using World Health Organization classifications. Participants were categorized by impairment on the Duke Activity Status Instrument (DASI: none, some, moderate, severe). Logistic regression models examined risk factors and GBD regions associated with functional impairment. The association between functional impairment and cardClinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaGeographical Differences in the Self-Reported Functional Impairment of People With Human Immunodeficiency Virus (HIV) and Associations With Cardiometabolic Risk.PMC9525090R01 AG054366UM1 AI069456UM1 AI106701UM1 AI068634UM1 AI068636U01 HL123339U01 HL123336U01HL123336P30DK 040561U01HL123339P30 DK040561UM1 AI069452UM1 AI069399UM1 AI069432UM1 AI069453Fitch KVAberg JAOverton ETBares SBloomfield GSFichtenbaum CJMave VGrinspoon SKFulda ESSantana-Bagur JLDouglas PSCastro JGErlandson KMBrown TTMcCallum SARibaudo HJSupparatpinyo KMoran LEPonatshego PLZanni MVSchechter MfalseGeographical Differences in the Self-Reported Functional Impairment of People With Human Immunodeficiency Virus (HIV) and Associations With Cardiometabolic Risk.<h4>Background</h4>We sought to explore multinational differences in functional status by global burden of disease (GBD) regions in the REPRIEVE cohort.<h4>Methods</h4>REPRIEVE is a prospective, double-blind, randomized, placebo-controlled, multicenter, phase III primary cardiovascular prevention study of pitavastatin calcium vs placebo among people with human immunodeficiency virus (HIV, PWH) ages 40-75 on antiretroviral therapy (ART). GBD super regions were defined using World Health Organization classifications. Participants were categorized by impairment on the Duke Activity Status Instrument (DASI: none, some, moderate, severe). Logistic regression models examined risk factors and GBD regions associated with functional impairment. The association between functional impairment and card2022-01-01T00:00:00Z2022 Sep2025-04-19T13:28:50.953Z2025-04-19T13:28:50.953ZS-EPMC95250903516568210.1093/cid/ciac098