biostudies-literatureChen CCChina Medical University Research Grants16399https://www.ebi.ac.uk/biostudies/studies/S-EPMC9525286biostudies-literatureUnknown12(1)Malignant brain tumors consist of malignancies originated primarily within the brain and the metastatic lesions disseminated from other organs. In spite of intensive studies, malignant brain tumors remain to be a medical challenge. Patient-derived organoid (PDO) can recapitulate the biological features of the primary tumor it was derived from and has emerged as a promising drug-screening model for precision therapy. Here we show a proof-of-concept based on early clinical study entailing the organoids derived from the surgically resected tumors of 26 patients with advanced malignant brain tumors enrolled during December 2020 to October 2021. The tumors included nine glioma patients, one malignant meningioma, one primary lymphoma patient, and 15 brain metastases. The primary tumor sites of tScientific reportsPatient-derived tumor organoids as a platform of precision treatment for malignant brain tumors.PMC9525286CMU107-UT-01Hsieh CLChen CCChen XXCho DYWang SCLi HWWang JWang YLShen YCWei STGuo JHHsieh CYLee CCLin HLfalsePatient-derived tumor organoids as a platform of precision treatment for malignant brain tumors.Malignant brain tumors consist of malignancies originated primarily within the brain and the metastatic lesions disseminated from other organs. In spite of intensive studies, malignant brain tumors remain to be a medical challenge. Patient-derived organoid (PDO) can recapitulate the biological features of the primary tumor it was derived from and has emerged as a promising drug-screening model for precision therapy. Here we show a proof-of-concept based on early clinical study entailing the organoids derived from the surgically resected tumors of 26 patients with advanced malignant brain tumors enrolled during December 2020 to October 2021. The tumors included nine glioma patients, one malignant meningioma, one primary lymphoma patient, and 15 brain metastases. The primary tumor sites of t2022-01-01T00:00:00Z2022 Sep2025-04-04T09:30:33.398Z2025-02-19T00:23:54.024ZS-EPMC95252863618051110.1038/s41598-022-20487-y