biostudies-literatureUnknown16(5)Su K<h4>Background</h4>Although the diagnostic value of plasma heat-shock protein 90α (HSP90α) in hepatocellular carcinoma (HCC) has been previously reported, the causal effect of the plasma HSP90α levels on HCC prognosis remains largely unclear. To this extent, we sought to assess whether the plasma HSP90α acts as a prognostic factor for HCC patients.<h4>Methods</h4>A total of 2150 HCC patients were included in this retrospective study between August 2016 and July 2021. Plasma HSP90α levels were tested within a week before treatment and their association with prognosis was assessed.<h4>Results</h4>An optimal cutoff value of 143.5 for the HSP90α based on the overall survival (OS) was determined using the X-tile software. HCC patients with HSP90α < 143.5 ng/mL (low HSP90α) before and after propHepatology international1208-1219https://www.ebi.ac.uk/biostudies/studies/S-EPMC9525341biostudies-literatureHeat-shock protein 90α is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study.PMC9525341Liu HWu MZhang JWang FSu KHan YChi HLiu YWu ZGuo LWang PJin HZheng HWen LTong JRao MChen SSong YTang XGu TXu KLi HChen JFeng XChen LHe KLi QYang BYang CLi XYang YHuang WZhu LTan ZZhang YLuo XXiong FPeng KXu YfalseHeat-shock protein 90α is a potential prognostic and predictive biomarker in hepatocellular carcinoma: a large-scale and multicenter study.<h4>Background</h4>Although the diagnostic value of plasma heat-shock protein 90α (HSP90α) in hepatocellular carcinoma (HCC) has been previously reported, the causal effect of the plasma HSP90α levels on HCC prognosis remains largely unclear. To this extent, we sought to assess whether the plasma HSP90α acts as a prognostic factor for HCC patients.<h4>Methods</h4>A total of 2150 HCC patients were included in this retrospective study between August 2016 and July 2021. Plasma HSP90α levels were tested within a week before treatment and their association with prognosis was assessed.<h4>Results</h4>An optimal cutoff value of 143.5 for the HSP90α based on the overall survival (OS) was determined using the X-tile software. HCC patients with HSP90α < 143.5 ng/mL (low HSP90α) before and after prop2022-01-01T00:00:00Z2022 Oct2025-04-22T03:40:28.84Z2025-02-19T00:24:07.701ZS-EPMC95253413597264010.1007/s12072-022-10391-y