biostudies-literatureHartrampf PEUniversitätsklinikum WürzburgInterdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum Würzburg4262-4270https://www.ebi.ac.uk/biostudies/studies/S-EPMC9525362biostudies-literatureUnknown49(12)<h4>Background</h4>Radioligand therapy (RLT) with ¹⁷⁷Lu-labeled prostate-specific membrane antigen (PSMA) ligands is associated with prolonged overall survival (OS) in patients with advanced, metastatic castration-resistant prostate cancer (mCRPC). A substantial number of patients, however, are prone to treatment failure. We aimed to determine clinical baseline characteristics to predict OS in patients receiving [¹⁷⁷Lu]Lu-PSMA I&T RLT in a long-term follow-up.<h4>Materials and methods</h4>Ninety-two mCRPC patients treated with [¹⁷⁷Lu]Lu-PSMA I&T with a follow-up of at least 18 months were retrospectively identified. Multivariable Cox regression analyses were performed for various baseline characteristics, including laboratory values, Gleason score, age, priEuropean journal of nuclear medicine and molecular imagingBaseline clinical characteristics predict overall survival in patients undergoing radioligand therapy with [¹⁷⁷Lu]Lu-PSMA I&T during long-term follow-up.PMC9525362Z-02/85Seitz AKKubler HWeinzierl FXSchirbel ARowe SPBuck AKSerfling SEHartrampf PEWerner RAfalseBaseline clinical characteristics predict overall survival in patients undergoing radioligand therapy with [¹⁷⁷Lu]Lu-PSMA I&T during long-term follow-up.<h4>Background</h4>Radioligand therapy (RLT) with ¹⁷⁷Lu-labeled prostate-specific membrane antigen (PSMA) ligands is associated with prolonged overall survival (OS) in patients with advanced, metastatic castration-resistant prostate cancer (mCRPC). A substantial number of patients, however, are prone to treatment failure. We aimed to determine clinical baseline characteristics to predict OS in patients receiving [¹⁷⁷Lu]Lu-PSMA I&T RLT in a long-term follow-up.<h4>Materials and methods</h4>Ninety-two mCRPC patients treated with [¹⁷⁷Lu]Lu-PSMA I&T with a follow-up of at least 18 months were retrospectively identified. Multivariable Cox regression analyses were performed for various baseline characteristics, including laboratory values, Gleason score, age, pri2022-01-01T00:00:00Z2022 Oct2025-04-22T09:38:58.06Z2024-11-15T00:42:20.898ZS-EPMC95253623565026310.1007/s00259-022-05853-2