biostudies-literatureRoh JNational Research Foundation of Korea42https://www.ebi.ac.uk/biostudies/studies/S-EPMC9525522biostudies-literatureUnknown9(1)In this study, we developed a highly stable polymeric vesicle using a nanosilica-armor membrane to achieve a sustainable colorimetric/luminescent response. The silica armor can be grown directly as ~ 5 nm spherical nanoparticles on the surface of the diacetylene (DA) vesicle with liposomal structure. This can be accomplished via the modified Stöber reaction in pure water on a layer of amine linkers deposited on the vesicles. Once formed, the structural stability of the DA vesicles dramatically increased and remained so even in a dried powder form that could be stored for a period of approximately 6 months. Then, redispersed in water, the armored vesicles did not agglomerate because of the electric charge of the silica armor. After polymerization, the polydiacetylene (PDA) vesicles maintainNano convergenceSustainable colorimetric/luminescent sensors enabled by armored lipid nanoparticles.PMC9525522NRF 2021R1A2C3009955Roh JCho YHAhn DJfalseSustainable colorimetric/luminescent sensors enabled by armored lipid nanoparticles.In this study, we developed a highly stable polymeric vesicle using a nanosilica-armor membrane to achieve a sustainable colorimetric/luminescent response. The silica armor can be grown directly as ~ 5 nm spherical nanoparticles on the surface of the diacetylene (DA) vesicle with liposomal structure. This can be accomplished via the modified Stöber reaction in pure water on a layer of amine linkers deposited on the vesicles. Once formed, the structural stability of the DA vesicles dramatically increased and remained so even in a dried powder form that could be stored for a period of approximately 6 months. Then, redispersed in water, the armored vesicles did not agglomerate because of the electric charge of the silica armor. After polymerization, the polydiacetylene (PDA) vesicles maintain2022-01-01T00:00:00Z2022 Sep2025-04-22T03:43:22.248Z2025-02-19T00:24:13.873ZS-EPMC95255223617855310.1186/s40580-022-00335-5