{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Han Z"],"funding":["Science and Technology Commission of Shanghai Municipality","National Natural Science Foundation of China"],"pagination":["100427"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9526170"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16"],"pubmed_abstract":["Wound healing and angiogenesis remain challenges for both clinical and experimental research worldwide. Periosteum-derived extracellular vesicles (P-sEVs) delivered by hydrogel dressings provide a potential strategy for wound defects to promote fast healing. In this study, we designed a NAGA/GelMA/Laponite/glycerol hydrogel wound dressing that can release P-sEVs to accelerate angiogenesis and wound healing (named P-sEVs@hydrogel) (<i>N</i>-acryloyl glycinamide, NAGA). The wound dressing showed multiple functions, including efficient angiogenesis, tissue adhesion and a physical barrier. P-sEVs significantly enhanced the proliferation, migration, and tube formation of endothelial cells <i>in vitro</i>. The results of <i>in vivo</i> experiments showed that P-sEVs@hydrogel accelerates the healing of a full-thickness defect wound model by stimulating the angiogenic process. The improved cell proliferation, tissue formation, remodeling, and re-epithelialization possibly resulted in the fast healing. This study shows that multifunctional hydrogel dressing combined with bioactive molecules can achieve fast and satisfactory wound healing in full-thickness wound defects and other related wounds."],"journal":["Materials today. Bio"],"pubmed_title":["Efficient angiogenesis-based wound healing through hydrogel dressing with extracellular vesicles release."],"pmcid":["PMC9526170"],"funding_grant_id":["82072422","2020PJD042","81572178","52075324"],"pubmed_authors":["Li X","Li Z","Zhang Z","Dong L","Li A","Fu L","Han Z"],"additional_accession":[]},"is_claimable":false,"name":"Efficient angiogenesis-based wound healing through hydrogel dressing with extracellular vesicles release.","description":"Wound healing and angiogenesis remain challenges for both clinical and experimental research worldwide. Periosteum-derived extracellular vesicles (P-sEVs) delivered by hydrogel dressings provide a potential strategy for wound defects to promote fast healing. In this study, we designed a NAGA/GelMA/Laponite/glycerol hydrogel wound dressing that can release P-sEVs to accelerate angiogenesis and wound healing (named P-sEVs@hydrogel) (<i>N</i>-acryloyl glycinamide, NAGA). The wound dressing showed multiple functions, including efficient angiogenesis, tissue adhesion and a physical barrier. P-sEVs significantly enhanced the proliferation, migration, and tube formation of endothelial cells <i>in vitro</i>. The results of <i>in vivo</i> experiments showed that P-sEVs@hydrogel accelerates the healing of a full-thickness defect wound model by stimulating the angiogenic process. The improved cell proliferation, tissue formation, remodeling, and re-epithelialization possibly resulted in the fast healing. This study shows that multifunctional hydrogel dressing combined with bioactive molecules can achieve fast and satisfactory wound healing in full-thickness wound defects and other related wounds.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-19T11:32:05.812Z","creation":"2025-02-19T00:23:41.332Z"},"accession":"S-EPMC9526170","cross_references":{"pubmed":["36193344"],"doi":["10.1016/j.mtbio.2022.100427"]}}