{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gautvik KM"],"funding":["NIA NIH HHS","Foundation for the National Institutes of Health","Sixth Framework Programme","Lovisenberg Diakonale Sykehus","Helse Sør-Øst RHF","Eli Lilly and Company"],"pagination":["23"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9526277"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["Background
A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied.Methods
Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12-13 weeks heavy-load strength exercise using Affymetrix microarrays. Three age groups, similarly trained, were compared: younger adults (age 24 ± 4 years), older adults of average age 70 years (Oslo cohort) and above 80 years (old BSU cohort). To increase statistical strength, one of the older cohorts was used for validation. In"],"journal":["European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity"],"pubmed_title":["Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults."],"pmcid":["PMC9526277"],"funding_grant_id":["LSHM-CT-2003-502941","AG15833","R01 AG018409","AG00831","52009/8029","AG18409"],"pubmed_authors":["Utheim TP","Pilling LC","Gautvik VT","Kvernevik KJ","Jones G","Raastad T","Raue U","Ravnum S","Reppe S","Wiig H","Trappe S","Olstad OK","Kirkegaard C","Gautvik KM"],"additional_accession":[]},"is_claimable":false,"name":"Heavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults.","description":"Background
A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied.Methods
Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12-13 weeks heavy-load strength exercise using Affymetrix microarrays. Three age groups, similarly trained, were compared: younger adults (age 24 ± 4 years), older adults of average age 70 years (Oslo cohort) and above 80 years (old BSU cohort). To increase statistical strength, one of the older cohorts was used for validation. In","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-05-31T02:25:28.16Z","creation":"2024-10-16T04:40:19.317Z"},"accession":"S-EPMC9526277","cross_references":{"pubmed":["36182918"],"doi":["10.1186/s11556-022-00304-1"]}}