biostudies-literatureGautvik KMNIA NIH HHSFoundation for the National Institutes of HealthSixth Framework ProgrammeLovisenberg Diakonale SykehusHelse Sør-Øst RHFEli Lilly and Company23https://www.ebi.ac.uk/biostudies/studies/S-EPMC9526277biostudies-literatureUnknown19(1)<h4>Background</h4>A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied.<h4>Methods</h4>Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12-13 weeks heavy-load strength exercise using Affymetrix microarrays. Three age groups, similarly trained, were compared: younger adults (age 24 ± 4 years), older adults of average age 70 years (Oslo cohort) and above 80 years (old BSU cohort). To increase statistical strength, one of the older cohorts was used for validation. InEuropean review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical ActivityHeavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults.PMC9526277LSHM-CT-2003-502941AG15833R01 AG018409AG0083152009/8029AG18409Utheim TPPilling LCGautvik VTKvernevik KJJones GRaastad TRaue URavnum SReppe SWiig HTrappe SOlstad OKKirkegaard CGautvik KMfalseHeavy-load exercise in older adults activates vasculogenesis and has a stronger impact on muscle gene expression than in young adults.<h4>Background</h4>A striking effect of old age is the involuntary loss of muscle mass and strength leading to sarcopenia and reduced physiological functions. However, effects of heavy-load exercise in older adults on diseases and functions as predicted by changes in muscle gene expression have been inadequately studied.<h4>Methods</h4>Thigh muscle global transcriptional activity (transcriptome) was analyzed in cohorts of older and younger adults before and after 12-13 weeks heavy-load strength exercise using Affymetrix microarrays. Three age groups, similarly trained, were compared: younger adults (age 24 ± 4 years), older adults of average age 70 years (Oslo cohort) and above 80 years (old BSU cohort). To increase statistical strength, one of the older cohorts was used for validation. In2022-01-01T00:00:00Z2022 Oct2026-05-31T02:25:28.16Z2024-10-16T04:40:19.317ZS-EPMC95262773618291810.1186/s11556-022-00304-1