{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Singh AT"],"funding":["NIDDK NIH HHS","NIH","NIDDK","NIH HHS"],"pagination":["1203-1208"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9526807"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(11)"],"pubmed_abstract":["<h4>Background</h4>Hypertension is common in hemodialysis (HD) patients. Increased blood pressure (BP) variability, particularly higher and lower extremes, is associated with adverse outcomes. We explored the association of endothelin-1 (ET-1), a potent vasoconstrictor, with different BP parameters (pre-HD, intra-HD, and post-HD) during HD in a contemporary patient cohort.<h4>Methods</h4>This study uses the DaVita Biorepository, a longitudinal prospective cohort study with quarterly collection of clinical data and biospecimens. Unadjusted and adjusted linear mixed effects regression models were fit to determine association of pre-HD ET-1 (log-transformed and quartiles) with HD-related systolic BP (SBP) parameters (pre-HD, nadir intra-HD, and post-HD). As ET-1 was measured at baseline, anal"],"journal":["American journal of hypertension"],"pubmed_title":["Endothelin-1 and Parameters of Systolic Blood Pressure in Hemodialysis."],"pmcid":["PMC9526807"],"funding_grant_id":["K23DK102511","DK085660","U01DK096189","CA229772","R03DK122240","DK127587"],"pubmed_authors":["Waikar SS","Mothi SS","Sabbisetti V","Li P","Singh AT","Mc Causland FR"],"additional_accession":[]},"is_claimable":false,"name":"Endothelin-1 and Parameters of Systolic Blood Pressure in Hemodialysis.","description":"<h4>Background</h4>Hypertension is common in hemodialysis (HD) patients. Increased blood pressure (BP) variability, particularly higher and lower extremes, is associated with adverse outcomes. We explored the association of endothelin-1 (ET-1), a potent vasoconstrictor, with different BP parameters (pre-HD, intra-HD, and post-HD) during HD in a contemporary patient cohort.<h4>Methods</h4>This study uses the DaVita Biorepository, a longitudinal prospective cohort study with quarterly collection of clinical data and biospecimens. Unadjusted and adjusted linear mixed effects regression models were fit to determine association of pre-HD ET-1 (log-transformed and quartiles) with HD-related systolic BP (SBP) parameters (pre-HD, nadir intra-HD, and post-HD). As ET-1 was measured at baseline, anal","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-21T18:52:12.096Z","creation":"2025-04-05T17:26:22.638Z"},"accession":"S-EPMC9526807","cross_references":{"pubmed":["34192305"],"doi":["10.1093/ajh/hpab104"]}}