biostudies-literatureSingh ATNIDDK NIH HHSNIHNIDDKNIH HHS1203-1208https://www.ebi.ac.uk/biostudies/studies/S-EPMC9526807biostudies-literatureUnknown34(11)<h4>Background</h4>Hypertension is common in hemodialysis (HD) patients. Increased blood pressure (BP) variability, particularly higher and lower extremes, is associated with adverse outcomes. We explored the association of endothelin-1 (ET-1), a potent vasoconstrictor, with different BP parameters (pre-HD, intra-HD, and post-HD) during HD in a contemporary patient cohort.<h4>Methods</h4>This study uses the DaVita Biorepository, a longitudinal prospective cohort study with quarterly collection of clinical data and biospecimens. Unadjusted and adjusted linear mixed effects regression models were fit to determine association of pre-HD ET-1 (log-transformed and quartiles) with HD-related systolic BP (SBP) parameters (pre-HD, nadir intra-HD, and post-HD). As ET-1 was measured at baseline, analAmerican journal of hypertensionEndothelin-1 and Parameters of Systolic Blood Pressure in Hemodialysis.PMC9526807K23DK102511DK085660U01DK096189CA229772R03DK122240DK127587Waikar SSMothi SSSabbisetti VLi PSingh ATMc Causland FRfalseEndothelin-1 and Parameters of Systolic Blood Pressure in Hemodialysis.<h4>Background</h4>Hypertension is common in hemodialysis (HD) patients. Increased blood pressure (BP) variability, particularly higher and lower extremes, is associated with adverse outcomes. We explored the association of endothelin-1 (ET-1), a potent vasoconstrictor, with different BP parameters (pre-HD, intra-HD, and post-HD) during HD in a contemporary patient cohort.<h4>Methods</h4>This study uses the DaVita Biorepository, a longitudinal prospective cohort study with quarterly collection of clinical data and biospecimens. Unadjusted and adjusted linear mixed effects regression models were fit to determine association of pre-HD ET-1 (log-transformed and quartiles) with HD-related systolic BP (SBP) parameters (pre-HD, nadir intra-HD, and post-HD). As ET-1 was measured at baseline, anal2021-01-01T00:00:00Z2021 Nov2025-04-21T18:52:12.096Z2025-04-05T17:26:22.638ZS-EPMC95268073419230510.1093/ajh/hpab104