{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kaze AD"],"funding":["Jackson Heart Study","Jackson State University","University of Mississippi Medical Center","Tougaloo College","National Heart, Lung, and Blood Institute","NHLBI NIH HHS","NIMHD NIH HHS","Mississippi State Department of Health","National Institutes of Health","NIH HHS","National Institute for Minority Health and Health Disparities"],"pagination":["1163-1170"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9526809"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(11)"],"pubmed_abstract":["<h4>Background</h4>Little is known on the association of plasma adiponectin with blood pressure (BP) changes in African Americans (AAs). We evaluated the associations between plasma adiponectin and BP progression among AAs.<h4>Methods</h4>We analyzed data from 1,184 participants without hypertension at baseline (2000-2004) with ≥1 follow-up visits in the Jackson Heart Study. We used robust Poisson regression to generate risk ratios (RRs) for BP progression (an increase by ≥1 BP stage) and incident hypertension.<h4>Results</h4>Over a median of 7 years, 71% progressed to higher BP stage and 65% developed hypertension. We found evidence of interaction by sex (P-interaction = 0.088). Compared with those in the lowest quartile (Q1), male participants in the highest adiponectin quartile (Q4) had reduced risks of BP progression (RR 0.76 [95% confidence interval, CI, 0.60-0.96]) and incident hypertension (RR 0.74 [95% CI 0.56-0.97]). After accounting for body mass index, this relation persisted among obese men (RR for the highest [vs. lowest] adiponectin quartile: 0.59 [95% CI 0.36-0.97] for incident hypertension, and 0.69 [95% CI 0.45-1.06] for BP progression). Among women, adiponectin was not associated with BP outcomes (RR [95% CI] for Q4 vs. Q1: 1.03 [0.86-1.23] and 1.01 [0.83-1.23] for BP progression and incident hypertension, respectively). Our findings were consistent across both the American College of Cardiology (ACC)/American Heart Association (AHA) and Seventh Joint National Committee (JNC-7) BP categories.<h4>Conclusions</h4>In a large, community-based sample of AAs, higher adiponectin concentrations were associated with lower risks of BP progression and incident hypertension in men, but no significant association was observed in women."],"journal":["American journal of hypertension"],"pubmed_title":["Plasma Adiponectin and Blood Pressure Progression in African Americans: The Jackson Heart Study."],"pmcid":["PMC9526809"],"funding_grant_id":["HHSN268201800015I","HHSN268201800012I","HHSN268201800011I","HHSN268201800014I","HHSN268201800013I","K23 HL153774","HHSN268201800010I"],"pubmed_authors":["Bertoni AG","Echouffo-Tcheugui JB","Musani SK","Golden SH","Correa A","Kaze AD","Bidulescu A"],"additional_accession":[]},"is_claimable":false,"name":"Plasma Adiponectin and Blood Pressure Progression in African Americans: The Jackson Heart Study.","description":"<h4>Background</h4>Little is known on the association of plasma adiponectin with blood pressure (BP) changes in African Americans (AAs). We evaluated the associations between plasma adiponectin and BP progression among AAs.<h4>Methods</h4>We analyzed data from 1,184 participants without hypertension at baseline (2000-2004) with ≥1 follow-up visits in the Jackson Heart Study. We used robust Poisson regression to generate risk ratios (RRs) for BP progression (an increase by ≥1 BP stage) and incident hypertension.<h4>Results</h4>Over a median of 7 years, 71% progressed to higher BP stage and 65% developed hypertension. We found evidence of interaction by sex (P-interaction = 0.088). Compared with those in the lowest quartile (Q1), male participants in the highest adiponectin quartile (Q4) had reduced risks of BP progression (RR 0.76 [95% confidence interval, CI, 0.60-0.96]) and incident hypertension (RR 0.74 [95% CI 0.56-0.97]). After accounting for body mass index, this relation persisted among obese men (RR for the highest [vs. lowest] adiponectin quartile: 0.59 [95% CI 0.36-0.97] for incident hypertension, and 0.69 [95% CI 0.45-1.06] for BP progression). Among women, adiponectin was not associated with BP outcomes (RR [95% CI] for Q4 vs. Q1: 1.03 [0.86-1.23] and 1.01 [0.83-1.23] for BP progression and incident hypertension, respectively). Our findings were consistent across both the American College of Cardiology (ACC)/American Heart Association (AHA) and Seventh Joint National Committee (JNC-7) BP categories.<h4>Conclusions</h4>In a large, community-based sample of AAs, higher adiponectin concentrations were associated with lower risks of BP progression and incident hypertension in men, but no significant association was observed in women.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-21T18:55:39.596Z","creation":"2025-04-05T17:25:15.742Z"},"accession":"S-EPMC9526809","cross_references":{"pubmed":["34166486"],"doi":["10.1093/ajh/hpab101"]}}