biostudies-literatureKaze ADJackson Heart StudyJackson State UniversityUniversity of Mississippi Medical CenterTougaloo CollegeNational Heart, Lung, and Blood InstituteNHLBI NIH HHSNIMHD NIH HHSMississippi State Department of HealthNational Institutes of HealthNIH HHSNational Institute for Minority Health and Health Disparities1163-1170https://www.ebi.ac.uk/biostudies/studies/S-EPMC9526809biostudies-literatureUnknown34(11)<h4>Background</h4>Little is known on the association of plasma adiponectin with blood pressure (BP) changes in African Americans (AAs). We evaluated the associations between plasma adiponectin and BP progression among AAs.<h4>Methods</h4>We analyzed data from 1,184 participants without hypertension at baseline (2000-2004) with ≥1 follow-up visits in the Jackson Heart Study. We used robust Poisson regression to generate risk ratios (RRs) for BP progression (an increase by ≥1 BP stage) and incident hypertension.<h4>Results</h4>Over a median of 7 years, 71% progressed to higher BP stage and 65% developed hypertension. We found evidence of interaction by sex (P-interaction = 0.088). Compared with those in the lowest quartile (Q1), male participants in the highest adiponectin quartile (Q4) had reduced risks of BP progression (RR 0.76 [95% confidence interval, CI, 0.60-0.96]) and incident hypertension (RR 0.74 [95% CI 0.56-0.97]). After accounting for body mass index, this relation persisted among obese men (RR for the highest [vs. lowest] adiponectin quartile: 0.59 [95% CI 0.36-0.97] for incident hypertension, and 0.69 [95% CI 0.45-1.06] for BP progression). Among women, adiponectin was not associated with BP outcomes (RR [95% CI] for Q4 vs. Q1: 1.03 [0.86-1.23] and 1.01 [0.83-1.23] for BP progression and incident hypertension, respectively). Our findings were consistent across both the American College of Cardiology (ACC)/American Heart Association (AHA) and Seventh Joint National Committee (JNC-7) BP categories.<h4>Conclusions</h4>In a large, community-based sample of AAs, higher adiponectin concentrations were associated with lower risks of BP progression and incident hypertension in men, but no significant association was observed in women.American journal of hypertensionPlasma Adiponectin and Blood Pressure Progression in African Americans: The Jackson Heart Study.PMC9526809HHSN268201800015IHHSN268201800012IHHSN268201800011IHHSN268201800014IHHSN268201800013IK23 HL153774HHSN268201800010IBertoni AGEchouffo-Tcheugui JBMusani SKGolden SHCorrea AKaze ADBidulescu AfalsePlasma Adiponectin and Blood Pressure Progression in African Americans: The Jackson Heart Study.<h4>Background</h4>Little is known on the association of plasma adiponectin with blood pressure (BP) changes in African Americans (AAs). We evaluated the associations between plasma adiponectin and BP progression among AAs.<h4>Methods</h4>We analyzed data from 1,184 participants without hypertension at baseline (2000-2004) with ≥1 follow-up visits in the Jackson Heart Study. We used robust Poisson regression to generate risk ratios (RRs) for BP progression (an increase by ≥1 BP stage) and incident hypertension.<h4>Results</h4>Over a median of 7 years, 71% progressed to higher BP stage and 65% developed hypertension. We found evidence of interaction by sex (P-interaction = 0.088). Compared with those in the lowest quartile (Q1), male participants in the highest adiponectin quartile (Q4) had reduced risks of BP progression (RR 0.76 [95% confidence interval, CI, 0.60-0.96]) and incident hypertension (RR 0.74 [95% CI 0.56-0.97]). After accounting for body mass index, this relation persisted among obese men (RR for the highest [vs. lowest] adiponectin quartile: 0.59 [95% CI 0.36-0.97] for incident hypertension, and 0.69 [95% CI 0.45-1.06] for BP progression). Among women, adiponectin was not associated with BP outcomes (RR [95% CI] for Q4 vs. Q1: 1.03 [0.86-1.23] and 1.01 [0.83-1.23] for BP progression and incident hypertension, respectively). Our findings were consistent across both the American College of Cardiology (ACC)/American Heart Association (AHA) and Seventh Joint National Committee (JNC-7) BP categories.<h4>Conclusions</h4>In a large, community-based sample of AAs, higher adiponectin concentrations were associated with lower risks of BP progression and incident hypertension in men, but no significant association was observed in women.2021-01-01T00:00:00Z2021 Nov2025-04-21T18:55:39.596Z2025-04-05T17:25:15.742ZS-EPMC95268093416648610.1093/ajh/hpab101