{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Knol R"],"funding":["Gisela Thier Fund","ZonMw"],"pagination":["838"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9526936"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>International guidelines recommend delayed umbilical cord clamping (DCC) up to 1 min in preterm infants, unless the condition of the infant requires immediate resuscitation. However, clamping the cord prior to lung aeration may severely limit circulatory adaptation resulting in a reduction in cardiac output and hypoxia. Delaying cord clamping until lung aeration and ventilation have been established (physiological-based cord clamping, PBCC) allows for an adequately established pulmonary circulation and results in a more stable circulatory transition. The decline in cardiac output following time-based delayed cord clamping (TBCC) may thus be avoided. We hypothesise that PBCC, compared to TBCC, results in a more stable transition in very preterm infants, leading to improve"],"journal":["Trials"],"pubmed_title":["Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial-study protocol for a multicentre randomised controlled trial."],"pmcid":["PMC9526936"],"funding_grant_id":["852001902"],"pubmed_authors":["Lopriore E","Onland W","Mulder EEM","Hutten GJ","van den Akker-van Marle ME","van Kaam AH","Hulzebos CV","de Boode WP","Hooper SB","Knol R","van Bodegom-Vos L","Te Pas AB","van der Putten ME","Brouwer E","Reiss IKM","DeKoninck PLJ","Prins SA","van den Akker T","Polglase GR","Vermeulen MJ","van Sambeeck SJ","Zonnenberg IA"],"additional_accession":[]},"is_claimable":false,"name":"Physiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial-study protocol for a multicentre randomised controlled trial.","description":"<h4>Background</h4>International guidelines recommend delayed umbilical cord clamping (DCC) up to 1 min in preterm infants, unless the condition of the infant requires immediate resuscitation. However, clamping the cord prior to lung aeration may severely limit circulatory adaptation resulting in a reduction in cardiac output and hypoxia. Delaying cord clamping until lung aeration and ventilation have been established (physiological-based cord clamping, PBCC) allows for an adequately established pulmonary circulation and results in a more stable circulatory transition. The decline in cardiac output following time-based delayed cord clamping (TBCC) may thus be avoided. We hypothesise that PBCC, compared to TBCC, results in a more stable transition in very preterm infants, leading to improve","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-06-01T02:10:29.78Z","creation":"2025-02-19T01:28:33.008Z"},"accession":"S-EPMC9526936","cross_references":{"pubmed":["36183143"],"doi":["10.1186/s13063-022-06789-6"]}}