biostudies-literatureKnol RGisela Thier FundZonMw838https://www.ebi.ac.uk/biostudies/studies/S-EPMC9526936biostudies-literatureUnknown23(1)<h4>Background</h4>International guidelines recommend delayed umbilical cord clamping (DCC) up to 1 min in preterm infants, unless the condition of the infant requires immediate resuscitation. However, clamping the cord prior to lung aeration may severely limit circulatory adaptation resulting in a reduction in cardiac output and hypoxia. Delaying cord clamping until lung aeration and ventilation have been established (physiological-based cord clamping, PBCC) allows for an adequately established pulmonary circulation and results in a more stable circulatory transition. The decline in cardiac output following time-based delayed cord clamping (TBCC) may thus be avoided. We hypothesise that PBCC, compared to TBCC, results in a more stable transition in very preterm infants, leading to improveTrialsPhysiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial-study protocol for a multicentre randomised controlled trial.PMC9526936852001902Lopriore EOnland WMulder EEMHutten GJvan den Akker-van Marle MEvan Kaam AHHulzebos CVde Boode WPHooper SBKnol Rvan Bodegom-Vos LTe Pas ABvan der Putten MEBrouwer EReiss IKMDeKoninck PLJPrins SAvan den Akker TPolglase GRVermeulen MJvan Sambeeck SJZonnenberg IAfalsePhysiological-based cord clamping in very preterm infants: the Aeration, Breathing, Clamping 3 (ABC3) trial-study protocol for a multicentre randomised controlled trial.<h4>Background</h4>International guidelines recommend delayed umbilical cord clamping (DCC) up to 1 min in preterm infants, unless the condition of the infant requires immediate resuscitation. However, clamping the cord prior to lung aeration may severely limit circulatory adaptation resulting in a reduction in cardiac output and hypoxia. Delaying cord clamping until lung aeration and ventilation have been established (physiological-based cord clamping, PBCC) allows for an adequately established pulmonary circulation and results in a more stable circulatory transition. The decline in cardiac output following time-based delayed cord clamping (TBCC) may thus be avoided. We hypothesise that PBCC, compared to TBCC, results in a more stable transition in very preterm infants, leading to improve2022-01-01T00:00:00Z2022 Oct2026-06-01T02:10:29.78Z2025-02-19T01:28:33.008ZS-EPMC95269363618314310.1186/s13063-022-06789-6