{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang L"],"funding":["the fundamental research funds for the central universities","Natural Science Foundation of Zhejiang Province of China","New talent in medical field of Zhejiang Province","Medical Healthy Scientific Technology project of Zhejiang Province","Zhejiang medical and health science and technology project"],"pagination":["433"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9526989"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application and still an ongoing challenge. In this work, an extraordinary injectable hydrogel PBNPs@OBG (Prussian blue nanoparticles@oxidized hyaluronic acid/borax/gelatin) with promising antibacterial, antioxidation, rapid gelation, and self-healing characteristics was designed via dual-dynamic-bond cross-linking among the oxidized hyaluronic acid (OHA), borax, and gelatin. The mechanical performance of the hydrogel was studied by dynamic mechanical analysis. Meanwhile, the swelling ratio and degradation level of the hydrogel was explored. Benefiting from its remarkable mechanical properties, sufficient tissue ad"],"journal":["Journal of nanobiotechnology"],"pubmed_title":["Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy."],"pmcid":["PMC9526989"],"funding_grant_id":["2019QNA7027","2018KY117, 2019ZD041","WKJ-ZJ-1906","LTY22E030002"],"pubmed_authors":["Yao L","Fan X","Yang L","Zhu Y","Chen J","Hu Z","Jin Y","Wang J","Zeng T","Yang W","Hu C","Xia J","Yu C"],"additional_accession":[]},"is_claimable":false,"name":"Dual-dynamic-bond cross-linked injectable hydrogel of multifunction for intervertebral disc degeneration therapy.","description":"Developing smart hydrogels with integrated and suitable properties to treat intervertebral disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical application and still an ongoing challenge. In this work, an extraordinary injectable hydrogel PBNPs@OBG (Prussian blue nanoparticles@oxidized hyaluronic acid/borax/gelatin) with promising antibacterial, antioxidation, rapid gelation, and self-healing characteristics was designed via dual-dynamic-bond cross-linking among the oxidized hyaluronic acid (OHA), borax, and gelatin. The mechanical performance of the hydrogel was studied by dynamic mechanical analysis. Meanwhile, the swelling ratio and degradation level of the hydrogel was explored. Benefiting from its remarkable mechanical properties, sufficient tissue ad","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-26T12:02:25.582Z","creation":"2025-02-19T00:24:04.235Z"},"accession":"S-EPMC9526989","cross_references":{"pubmed":["36182921"],"doi":["10.1186/s12951-022-01633-0"]}}