{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bennike TB"],"funding":["NIDDK NIH HHS"],"pagination":["435-444"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9527096"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(5)"],"pubmed_abstract":["<h4>Objectives</h4>Total pancreatectomy with islet autotransplantation (TPIAT) is a surgical option for refractory chronic pancreatitis-related pain. Despite the known clinical implications of TPIAT, the molecular effects remain poorly investigated. We performed the first hypothesis-generating study of the urinary proteome before and after TPIAT.<h4>Methods</h4>Twenty-two patients eligible for TPIAT were prospectively enrolled. Urine samples were collected the week before and 12 to 18 months after TPIAT. The urine samples were prepared for bottom-up label-free quantitative proteomics using the \"MStern\" protocol.<h4>Results</h4>Using 17 paired samples, we identified 2477 urinary proteins, of which 301 were significantly changed post-TPIAT versus pre-TPIAT. Our quantitative analysis revealed"],"journal":["Pancreas"],"pubmed_title":["Urine Proteomics Reveals Sex-Specific Response to Total Pancreatectomy With Islet Autotransplantation."],"pmcid":["PMC9527096"],"funding_grant_id":["U01 DK108327","U01 DK126300"],"pubmed_authors":["Grover AS","Steen H","Ahmed S","Cruz-Monserrate Z","Templeton K","Bellin MD","Arnaout R","Conwell DL","Schlaffner CN","Arora R","Bennike TB","Beilman GJ","Fujimura K"],"additional_accession":[]},"is_claimable":false,"name":"Urine Proteomics Reveals Sex-Specific Response to Total Pancreatectomy With Islet Autotransplantation.","description":"<h4>Objectives</h4>Total pancreatectomy with islet autotransplantation (TPIAT) is a surgical option for refractory chronic pancreatitis-related pain. Despite the known clinical implications of TPIAT, the molecular effects remain poorly investigated. We performed the first hypothesis-generating study of the urinary proteome before and after TPIAT.<h4>Methods</h4>Twenty-two patients eligible for TPIAT were prospectively enrolled. Urine samples were collected the week before and 12 to 18 months after TPIAT. The urine samples were prepared for bottom-up label-free quantitative proteomics using the \"MStern\" protocol.<h4>Results</h4>Using 17 paired samples, we identified 2477 urinary proteins, of which 301 were significantly changed post-TPIAT versus pre-TPIAT. Our quantitative analysis revealed","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-05-28T01:56:38.944Z","creation":"2026-04-08T02:07:57.574Z"},"accession":"S-EPMC9527096","cross_references":{"pubmed":["35881699"],"doi":["10.1097/mpa.0000000000002063","10.1097/MPA.0000000000002063"]}}