biostudies-literaturePatrier JDirection générale des armées (france)Direction générale des armées300https://www.ebi.ac.uk/biostudies/studies/S-EPMC9527714biostudies-literatureUnknown26(1)<h4>Background</h4>The composition of the digestive microbiota may be associated with outcome and infections in patients admitted to the intensive care unit (ICU). The dominance by opportunistic pathogens (such as Enterococcus) has been associated with death. However, whether this association remains all throughout the hospitalization are lacking.<h4>Methods</h4>We performed a single-center observational prospective cohort study in critically ill patients admitted with severe SARS-CoV-2 infection. Oropharyngeal and rectal swabs were collected at admission and then twice weekly until discharge or death. Quantitative cultures for opportunistic pathogens were performed on oropharyngeal and rectal swabs. The composition of the intestinal microbiota was assessed by 16S rDNA sequencing. OropharyCritical care (London, England)Oropharyngeal and intestinal concentrations of opportunistic pathogens are independently associated with death of SARS-CoV-2 critically ill adults.PMC9527714project FastGeneIIVillageois-Tran KJaafoura SRuppe EEloy PMouquet HDorival CLe Hingrat Qde Montmollin EDeplanque DSu RPatrier JGoehringer FLaouenan CChirouze CLina BFlorence AMPaul CArmand-Lefevre LBeluze MDiallo APetrov-Sanchez VGueye SCervantes-Gonzalez MRosa-Calatrava MLe MLevy YWicky PHBartoli MTimsit JFLafhej NAbel LAndrejak CGschwind RMalvy DBouadma LRossignol PTardivon CCouffignal CGigante THoffmann ILe Mestre SEsperou HLingas Gda Silva FDHouas IRossignol BSonneville REtienne MWiedemann AKhalil AChair ADebray MPGilg MBehilill SBachelet DMentre FGaymard AHulot JSEsposito-Farese MSzychowiak PRuckly SNeant NLaribi SAbrous ACharpentier CEnouf VMarzouk MPeytavin GLamara FPicone OFrench COVID Cohort Study GroupChenard LDescamps DRoy CTubiana SAngoulvant FSchneider MLetrou SVisseaux BBhavsar KCouffin-Cadiergues SDuval XKafif OGhosn JGuedj JPapadopoulos APiquard VVan Der Werf SPetitjean MfalseOropharyngeal and intestinal concentrations of opportunistic pathogens are independently associated with death of SARS-CoV-2 critically ill adults.<h4>Background</h4>The composition of the digestive microbiota may be associated with outcome and infections in patients admitted to the intensive care unit (ICU). The dominance by opportunistic pathogens (such as Enterococcus) has been associated with death. However, whether this association remains all throughout the hospitalization are lacking.<h4>Methods</h4>We performed a single-center observational prospective cohort study in critically ill patients admitted with severe SARS-CoV-2 infection. Oropharyngeal and rectal swabs were collected at admission and then twice weekly until discharge or death. Quantitative cultures for opportunistic pathogens were performed on oropharyngeal and rectal swabs. The composition of the intestinal microbiota was assessed by 16S rDNA sequencing. Orophary2022-01-01T00:00:00Z2022 Oct2026-05-31T17:03:22.975Z2024-11-07T03:09:35.027ZS-EPMC95277143619275610.1186/s13054-022-04164-0