{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wauters AC"],"funding":["European Research Council","Ministerie van Onderwijs, Cultuur en Wetenschap"],"pagination":["15072-15085"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9527792"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(9)"],"pubmed_abstract":["Nanosized artificial antigen-presenting cells (aAPCs), synthetic immune cell mimics that aim to activate T cells <i>ex</i> or <i>in vivo</i>, offer an effective alternative to cellular immunotherapies. However, comprehensive studies that delineate the effect of nano-aAPC topology, including nanoparticle morphology and ligand density, are lacking. Here, we systematically studied the topological effects of polymersome-based aAPCs on T cell activation. We employed an aAPC library created from biodegradable poly(ethylene glycol)-<i>block</i>-poly(d,l-lactide) (PEG-PDLLA) polymersomes with spherical or tubular shape and variable sizes, which were functionalized with αCD3 and αCD28 antibodies at controlled densities. Our results indicate that high ligand density leads to enhancement in T cell ac"],"journal":["ACS nano"],"pubmed_title":["Artificial Antigen-Presenting Cell Topology Dictates T Cell Activation."],"pmcid":["PMC9527792"],"funding_grant_id":["024.001.035","802791","694120"],"pubmed_authors":["Abdelmohsen LKEA","Wauters AC","Vermeijlen IG","Schluck M","Scheerstra JF","Albertazzi L","Figdor CG","Tel J","Woythe L","Hammink R","Wu H","van Hest JCM"],"additional_accession":[]},"is_claimable":false,"name":"Artificial Antigen-Presenting Cell Topology Dictates T Cell Activation.","description":"Nanosized artificial antigen-presenting cells (aAPCs), synthetic immune cell mimics that aim to activate T cells <i>ex</i> or <i>in vivo</i>, offer an effective alternative to cellular immunotherapies. However, comprehensive studies that delineate the effect of nano-aAPC topology, including nanoparticle morphology and ligand density, are lacking. Here, we systematically studied the topological effects of polymersome-based aAPCs on T cell activation. We employed an aAPC library created from biodegradable poly(ethylene glycol)-<i>block</i>-poly(d,l-lactide) (PEG-PDLLA) polymersomes with spherical or tubular shape and variable sizes, which were functionalized with αCD3 and αCD28 antibodies at controlled densities. Our results indicate that high ligand density leads to enhancement in T cell ac","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T11:30:37.421Z","creation":"2025-04-19T11:30:37.421Z"},"accession":"S-EPMC9527792","cross_references":{"pubmed":["35969506"],"doi":["10.1021/acsnano.2c06211"]}}