{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16"],"submitter":["Li R"],"pubmed_abstract":["By the introduction of the -<i>t</i>Bu groups into aza-BODIPY core, di-<i>tert</i>-butyl-substituted aza-BODIPYs at 3,5-sites (<b>tBuazaBDP</b>s) were prepared for the first time. Based on the X-ray analysis of <b>CN-tBuazaBDP</b>, this molecular structure is twisted. Near-infrared dye <b>SMe-tBuazaBDP</b> has the ultra-large Stokes shift (152 ​nm) in aza-BODIPY system, combining with the twisted intramolecular charge transfer and the free rotation of the <i>-t</i>Bu groups at 3,5-sites. Although the barrier-free rotors of the distal <i>-t</i>Bu groups in <b>SMe-tBuazaBDP</b> result in low fluorescence quantum yield, the photothermal conversion efficiency is markedly enhanced. <b>SMe-tBuazaBDP</b> nanoparticles with low power laser irradiation were proven to block cancer cell cycle, inhibi"],"journal":["Materials today. Bio"],"pagination":["100446"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9527945"],"repository":["biostudies-literature"],"pubmed_title":["Attachment of -<i>t</i>Bu groups to aza-BODIPY core at 3,5-sites with ultra-large Stokes shift to enhance photothermal therapy through apoptosis mechanism."],"pmcid":["PMC9527945"],"pubmed_authors":["Zhang D","Lv M","Ren J","Jiang XD","Wang G","Li R","Wang H","Du J","Zhang S","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Attachment of -<i>t</i>Bu groups to aza-BODIPY core at 3,5-sites with ultra-large Stokes shift to enhance photothermal therapy through apoptosis mechanism.","description":"By the introduction of the -<i>t</i>Bu groups into aza-BODIPY core, di-<i>tert</i>-butyl-substituted aza-BODIPYs at 3,5-sites (<b>tBuazaBDP</b>s) were prepared for the first time. Based on the X-ray analysis of <b>CN-tBuazaBDP</b>, this molecular structure is twisted. Near-infrared dye <b>SMe-tBuazaBDP</b> has the ultra-large Stokes shift (152 ​nm) in aza-BODIPY system, combining with the twisted intramolecular charge transfer and the free rotation of the <i>-t</i>Bu groups at 3,5-sites. Although the barrier-free rotors of the distal <i>-t</i>Bu groups in <b>SMe-tBuazaBDP</b> result in low fluorescence quantum yield, the photothermal conversion efficiency is markedly enhanced. <b>SMe-tBuazaBDP</b> nanoparticles with low power laser irradiation were proven to block cancer cell cycle, inhibi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-19T10:00:27.231Z","creation":"2024-11-21T02:21:24.788Z"},"accession":"S-EPMC9527945","cross_references":{"pubmed":["36199559"],"doi":["10.1016/j.mtbio.2022.100446"]}}