biostudies-literatureSoomro QHNational Health and Medical Research Council of AustraliaU.S. Department of Veterans Affairs Cooperative Studies Program1446-1456https://www.ebi.ac.uk/biostudies/studies/S-EPMC9528263biostudies-literatureUnknown17(10)<h4>Background and objectives</h4>Contrast-associated AKI may result in higher morbidity and mortality. Intravenous fluid administration remains the mainstay for prevention. There is a lack of consensus on the optimal administration strategy. We studied the association of periprocedure fluid administration with contrast-associated AKI, defined as an increase in serum creatinine of at least 25% or 0.5 mg/dl from baseline at 3-5 days after angiography, and 90-day need for dialysis, death, or a 50% increase in serum creatinine.<h4>Design, setting, participants, & measurements</h4>We conducted a secondary analysis of 4671 PRESERVE participants who underwent angiographic procedures. Although fluid type was randomized, strategy of administration was at the discretion of the clinician. We dividedClinical journal of the American Society of Nephrology : CJASNThe Relationship between Rate and Volume of Intravenous Fluid Administration and Kidney Outcomes after Angiography.PMC9528263APP1011387CSP 578Bailey CModrall JGMusameh MPlunkett SMussap CBurgess SPrasan AArmstrong AFerrier KO'Meeghan TUretsky BHerrmann RCass AOstrowski SXu KNadella NBalakrishnan DMa SKXu JAhmad WAWKreuch JZheng-Phelan LBroussard EMohammad MBHuq RHincks CMiller KMenees DMiller MPatten CAyoub CMay ADobinson KBartlett PStockle PWillatt JRoss SBath JWong COverberger PParikh CTurner KParikh DVrachas DRoss JSherigar RCiniglio RWalczyk JInting-Toothman SGallagher MLui CKibbe MQuinn MLatif FJudd JKlein ALendvai DBeals DO'Shea COliveros RMavromatis KBarry LCheong SYStraiton NRao SHillis GChertow GYianni ASoliva SHailes MRaghavan SLit YAnscomise RHenson SAgarwal APirakh CBrophy MLoxton ANelson GHecht JHayat MUTsai SKenworthy-Heinige TJardine MSoto-Gonzalez MEllis KPRESERVE Trial InvestigatorsChandrala PLee HYGarcia SHuo EGreenwell DCoulshed DMcFalls ERothenberg FChen AIdleman LMartinez LGarcia EArif ICurrier JAtkinson TSumption KWarner APalevsky PCurry TBreall JJohnson JAl-Fiadh AJohnson LHallani HFelice KAMansor SMSMikhail AJohnson PForrest NAnderson SFawcett MMukerji RBrilakis ELeung DSmyth BCoggan SSmyth DGallagher MPCroce KMalarchick JASoomro QHAlavi HRivero MBrieger DErickson RPHMNallamothu BHammad NATulloch GDenktas AVokonas PVercher PBandi RJuneman ERatliff MWaidmann KAhmed ZLarsen GWoerner DBratcher KShah RAnand STHuynh CKaufman JRowe CZimmet JKassim ZAZuhdi ASMPham TChung HYLehmann KIhdayid ARPham SGoldman SConway BCooke BJozic JBottomley SBadie TLohr JTerluk ADanson EMaldonado MWollaston FMcNear JMendes KLo SDev DPrideaux JForsberg MBeatty AKumaran VAristy KRousan TMau JLehnhard SAdabag SKrishnamurthy VGuenther SRatib KThomas MWalsworth MShaw EWescott LMotaganahalli RChang DYahaya NFernandes VSzymanski KBundy MTran DRoesle MHand SGunton JFrodsham AStewart RAitken ASingh AWilliam MBarua RHelmy TSimmonds MBCresp DAitken SSaklayen MJneid HShunk KFaxon DGalla ASasse AGiacomini JYusuf AJovin IChilakapati VRanchord AOchalek TO'Donoghue MHorsfall LALim SKDow JKong PKWebster JNoe SCondon DGovindasamy PParashara DTaverner PShrestha PMackenzie MBrennan JGanda PYates CChoi CYoussef GHarrison TBarrett DWard MSedlis SFearon WRamsay DThakar CGhapar AKVickers CPrakash RStanley KStone LRosenthal NJones WSSmith BKanna RKetteler EHyat UMadabhushi AYan WBinnekamp MRinger RLusk CLau JShah BLumb NHenley KAllahwala UYong CAnastasius MKeary MWeisbord SElsokkari IJames EWright TCroucher AFuah KRamirez-Jimenez AWahab MJALee VZNyakudarika EGarbelotti KPaniagua DWright CRaicu MYousaf MErshad SMcPhee JChin MHaq HBBAVelarde KSubbarao RMani KBellomo RNasir AWilliams VHendrix MRamkaransingh JFeldman GCloen DCatania DTsuda RJones DHamilton MLara-Smalling ARoy JMathew JMwaijele LHabizal NHHall DRoy PKotwal SAhmadsha SHLim RYDaud SRKrucoff MBerg MHadi MFChew DFerguson REnglish BKumar NNParikh CRMcCullough PTalaulikar GFitzpatrick DKirby AKinatra VPearson LGurm HO'Connor JVentura NLy SGoff JBenatar JBavry APeters TPhang CNaser MNMAfaq MSinan AARider KDulin HHowell LGupta NCorin WMarlow JCompton JMaranan LMiddleditch DPalevsky PMJones NFernandes CMassaband PVanGaal WSnider RRamanathan KSridhar GSHashim HPRESERVE Trial GroupScott PDiBona AAbidin IZYudi MAtwell AQualls ZJackson CIbrahim NABKrupka AMulukutla SDuvernoy CWhitley AChou TThadani UMatsis PRoys MDempsey EFine MMalik FNaria SLew RMazhar JJeter DMeyeraan TGhani ARACavalieri SRobertson DNava ARaffetto JReid EAdnan WAHWMVaitkus PThal SUnterbrink KTernouth IRaynes SO'Brien KPlotz MSebastian JKudryk BKinlay SKapoor DHa JMy-Do JNielsen CSandoval MIsmail MDGriza DVenn-Edmonds CWeaver JMurphy DAbu-Fadel MHassan FCMinisi AMandawat MFerguson REAalami ODavies CDavies BExaire JStadius MLee JGrossman PMBolad ILee BLee AConner TVernon SPowell MLee LHJarmukli NMonteverde EPitts AMureebe LRangasamy KZhou WGoh CAWilkins BAlyward POni OVidovich MZappernick TVakil KHendriks RRaman BCorbelli JTruong HTFarouque OWu JLorin JHuang JChadwick HWolbinski MKumar MFord TSader MArena FDishongh KWu HSurineni KGoldberg JKang PHakeem ASundaralingam STsay IMLowe HNg BRahman AKrier CKalman JPark KAbdulla ZBKader MASAPathan FEskelson NFairley SWatnick SKaufman JSSierzega RTan SLHorrigan MJuergens CGalvin GFarshid ABhatt DSawhney RFrench JMallard TVargo KSubiakto IBonner MWoklu NWeisbord SDCalkins JKissajukian FThai HIsmail OWillis CMcGee JHarding SCapuno MRose PBanerjee SKipps JAtique SNguyen JChilton RDosluoglu HCherry JKumar GBrown LPovsic TDias PBhatt DLPalmer LPathik BfalseThe Relationship between Rate and Volume of Intravenous Fluid Administration and Kidney Outcomes after Angiography.<h4>Background and objectives</h4>Contrast-associated AKI may result in higher morbidity and mortality. Intravenous fluid administration remains the mainstay for prevention. There is a lack of consensus on the optimal administration strategy. We studied the association of periprocedure fluid administration with contrast-associated AKI, defined as an increase in serum creatinine of at least 25% or 0.5 mg/dl from baseline at 3-5 days after angiography, and 90-day need for dialysis, death, or a 50% increase in serum creatinine.<h4>Design, setting, participants, & measurements</h4>We conducted a secondary analysis of 4671 PRESERVE participants who underwent angiographic procedures. Although fluid type was randomized, strategy of administration was at the discretion of the clinician. We divided2022-01-01T00:00:00Z2022 Oct2026-05-28T02:04:40.304Z2024-12-04T04:08:12.563ZS-EPMC95282633600835210.2215/CJN.0216022210.2215/cjn.02160222