{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang E"],"funding":["Department of Education of Guizhou Province","National Natural Science Foundation of China"],"pagination":["28098-28103"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9528730"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(43)"],"pubmed_abstract":["We report herein an efficient polyphosphoric acid (PPA) promoted one-pot protocol for the synthesis of flavanone derivatives from 2-hydroxyacetophenones and benzaldehydes. A variety of flavanones were produced in moderate to excellent yields and evaluated for their neuroprotective effects against <i>N</i>-methyl-d-aspartate (<i>N</i>MDA)-induced excitotoxicity in PC12 cells. Derivatives bearing electron-donating groups exhibited better neuroprotective activity. Compound 3m demonstrated the best protective potency and reversed the intracellular calcium (Ca<sup>2+</sup>) influx caused by NMDA, suggesting that flavanones protected the PC12 cells against NMDA-induced neurotoxicity <i>via</i> inhibition of Ca<sup>2+</sup> overload."],"journal":["RSC advances"],"pubmed_title":["Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells."],"pmcid":["PMC9528730"],"funding_grant_id":["81860609","QJHKYZ[2020]018"],"pubmed_authors":["Yang X","Yang L","Luo J","Gan M","Lei Y","Wang E","Song S","Yang Q","Wang X","Yang F"],"additional_accession":[]},"is_claimable":false,"name":"Polyphosphoric acid-promoted one-pot synthesis and neuroprotective effects of flavanones against NMDA-induced injury in PC12 cells.","description":"We report herein an efficient polyphosphoric acid (PPA) promoted one-pot protocol for the synthesis of flavanone derivatives from 2-hydroxyacetophenones and benzaldehydes. A variety of flavanones were produced in moderate to excellent yields and evaluated for their neuroprotective effects against <i>N</i>-methyl-d-aspartate (<i>N</i>MDA)-induced excitotoxicity in PC12 cells. Derivatives bearing electron-donating groups exhibited better neuroprotective activity. Compound 3m demonstrated the best protective potency and reversed the intracellular calcium (Ca<sup>2+</sup>) influx caused by NMDA, suggesting that flavanones protected the PC12 cells against NMDA-induced neurotoxicity <i>via</i> inhibition of Ca<sup>2+</sup> overload.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-05-31T16:00:06.057Z","creation":"2025-04-04T12:46:04.192Z"},"accession":"S-EPMC9528730","cross_references":{"pubmed":["36320275"],"doi":["10.1039/d2ra03562f"]}}