{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(9)"],"submitter":["Tong C"],"funding":["Priority Academic Program Development of Jiangsu Higher Education Institutions"],"pubmed_abstract":["In most plants, sucrose, a major storage sugar, is transported into sink organs to support their growth. This key physiological process is dependent on the function of sucrose transporters. Sucrose export from source tissues is predominantly controlled through the activity of SUCROSE TRANSPORTER 2 (SUC2), required for the loading of sucrose into the phloem of Arabidopsis plants. However, how SUC2 activity is controlled to support root growth remains unclear. Glucose is perceived via the function of HEXOKINASE 1 (HXK1), the only known nuclear glucose sensor. HXK1 negatively regulates the stability of ETHYLENE-INSENSITIVE3 (EIN3), a key ethylene/glucose interaction component. Here we show that HXK1 functions upstream of EIN3 in the regulation of root sink growth mediated by glucose signaling"],"journal":["PLoS genetics"],"pagination":["e1010424"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9529141"],"repository":["biostudies-literature"],"pubmed_title":["Long-distance transport of sucrose in source leaves promotes sink root growth by the EIN3-SUC2 module."],"pmcid":["PMC9529141"],"pubmed_authors":["Mu XR","Meng LS","Tong C","Liu CY","Li C","Sun XD","Chen HH","Cao XY","Bao QX","Loake GJ"],"additional_accession":[]},"is_claimable":false,"name":"Long-distance transport of sucrose in source leaves promotes sink root growth by the EIN3-SUC2 module.","description":"In most plants, sucrose, a major storage sugar, is transported into sink organs to support their growth. This key physiological process is dependent on the function of sucrose transporters. Sucrose export from source tissues is predominantly controlled through the activity of SUCROSE TRANSPORTER 2 (SUC2), required for the loading of sucrose into the phloem of Arabidopsis plants. However, how SUC2 activity is controlled to support root growth remains unclear. Glucose is perceived via the function of HEXOKINASE 1 (HXK1), the only known nuclear glucose sensor. HXK1 negatively regulates the stability of ETHYLENE-INSENSITIVE3 (EIN3), a key ethylene/glucose interaction component. Here we show that HXK1 functions upstream of EIN3 in the regulation of root sink growth mediated by glucose signaling","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-19T11:33:47.989Z","creation":"2025-04-19T11:33:47.989Z"},"accession":"S-EPMC9529141","cross_references":{"pubmed":["36129930"],"doi":["10.1371/journal.pgen.1010424"]}}