{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Uto M"],"funding":["Japan Society for the Promotion of Science London"],"pagination":["987-994"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9529683"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(10)"],"pubmed_abstract":["The prognosis of patients with brain metastases has dramatically improved, and long-term tumor control and reduction of the risk of late toxicities, including neurocognitive dysfunction, are important for patient quality of life. Stereotactic irradiation for multiple brain metastases, rather than whole-brain radiotherapy, can result in high local control rate with low incidence of neurocognitive deterioration and leukoencephalopathy. Recent advances in radiotherapy devices, treatment-planning systems, and image-guided radiotherapy can realize single isocenter stereotactic irradiation for multiple brain metastases (SI-STI-MBM), in which only one isocenter is sufficient to treat multiple brain metastases simultaneously. SI-STI-MBM has expanded the indications for linear accelerator-based stereotactic irradiation and considerably reduced patient burden. This review summarizes the background, methods, clinical outcomes, and specific consideration points of SI-STI-MBM. In addition, the prospects of SI-STI-MBM are addressed."],"journal":["Japanese journal of radiology"],"pubmed_title":["Single isocenter stereotactic irradiation for multiple brain metastases: current situation and prospects."],"pmcid":["PMC9529683"],"funding_grant_id":["21K15548"],"pubmed_authors":["Mizowaki T","Uto M","Torizuka D"],"additional_accession":[]},"is_claimable":false,"name":"Single isocenter stereotactic irradiation for multiple brain metastases: current situation and prospects.","description":"The prognosis of patients with brain metastases has dramatically improved, and long-term tumor control and reduction of the risk of late toxicities, including neurocognitive dysfunction, are important for patient quality of life. Stereotactic irradiation for multiple brain metastases, rather than whole-brain radiotherapy, can result in high local control rate with low incidence of neurocognitive deterioration and leukoencephalopathy. Recent advances in radiotherapy devices, treatment-planning systems, and image-guided radiotherapy can realize single isocenter stereotactic irradiation for multiple brain metastases (SI-STI-MBM), in which only one isocenter is sufficient to treat multiple brain metastases simultaneously. SI-STI-MBM has expanded the indications for linear accelerator-based stereotactic irradiation and considerably reduced patient burden. This review summarizes the background, methods, clinical outcomes, and specific consideration points of SI-STI-MBM. In addition, the prospects of SI-STI-MBM are addressed.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-05-29T16:10:27.499Z","creation":"2025-04-07T12:25:20.285Z"},"accession":"S-EPMC9529683","cross_references":{"pubmed":["36057071"],"doi":["10.1007/s11604-022-01333-7"]}}