{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yamamoto R"],"funding":["NHGRI NIH HHS","U.S. Department of Health &amp; Human Services | NIH | National Human Genome Research Institute","NIGMS NIH HHS"],"pagination":["5803"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9530233"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Age is the primary risk factor for many common human diseases. Here, we quantify the relative contributions of genetics and aging to gene expression patterns across 27 tissues from 948 humans. We show that the predictive power of expression quantitative trait loci is impacted by age in many tissues. Jointly modelling the contributions of age and genetics to transcript level variation we find expression heritability (h<sup>2</sup>) is consistent among tissues while the contribution of aging varies by >20-fold with [Formula: see text] in 5 tissues. We find that while the force of purifying selection is stronger on genes expressed early versus late in life (Medawar's hypothesis), several highly proliferative tissues exhibit the opposite pattern. These non-Medawarian tissues exhibit high rates"],"journal":["Nature communications"],"pubmed_title":["Tissue-specific impacts of aging and genetics on gene expression patterns in humans."],"pmcid":["PMC9530233"],"funding_grant_id":["R00 HG009677","R35GM142916","R35 GM142916","R00HG009677"],"pubmed_authors":["Sudmant PH","Sheng H","Ioannidis NM","Chung R","Vazquez JM","Steinberg PL","Yamamoto R"],"additional_accession":[]},"is_claimable":false,"name":"Tissue-specific impacts of aging and genetics on gene expression patterns in humans.","description":"Age is the primary risk factor for many common human diseases. Here, we quantify the relative contributions of genetics and aging to gene expression patterns across 27 tissues from 948 humans. We show that the predictive power of expression quantitative trait loci is impacted by age in many tissues. Jointly modelling the contributions of age and genetics to transcript level variation we find expression heritability (h<sup>2</sup>) is consistent among tissues while the contribution of aging varies by >20-fold with [Formula: see text] in 5 tissues. We find that while the force of purifying selection is stronger on genes expressed early versus late in life (Medawar's hypothesis), several highly proliferative tissues exhibit the opposite pattern. These non-Medawarian tissues exhibit high rates","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-06-03T10:38:57.725Z","creation":"2025-04-26T23:58:48.577Z"},"accession":"S-EPMC9530233","cross_references":{"pubmed":["36192477"],"doi":["10.1038/s41467-022-33509-0"]}}